Francine Shapiro Library

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1. Landin-Romero, R., Novo, P., Santed, A., Vicens, V., McKenna, P. J., Pomarol-Clotet, E., Salgado-Pineda, P., Shapiro, F., & Amann, B. (2012, June). Clinical remission and functional modulation of the default mode network in a subsyndromal, traumatized bipolar patient after EMDR psychotherapy. Poster presented at the annual meeting of EMDR Europe, Madrid, Spain .

Language: English

Format: Conference

Abstract: Purpose of the study: Some patients with bipolar disorder do not show complete remission between episodes, but continue to exhibit subsyndromal mood symptoms [1]. One factor related may be comorbid posttraumatic stress disorder (PTSD), which has been found to be present in 16% to 39% of patients with bipolar disorder [2]. We describe the first case of an unstable bipolar II patient with history of various traumas that received Eye Movement Desensitization and Reprocessing (EMDR) psychotherapy and also underwent functional magnetic resonance imaging (fMRI) before and after the EMDR treatment to explore its effect on the brain’s neural networks.

Keywords: Bipolar Disorder  

Accuracy Verified: Yes

2. Jatzko, A., Ruf, M., & Schmitt, A. (2008, Mai). Durch EMDR normalisierte funktionelle verarbeitungsprozesse bei PTBS: Eine fMRT pilotstudie [EMDR normalized by functional processing in PTSD: An fMRI pilot study] . Poster präsentiert auf der 10. Jahrestagung der DeGPT Deutschsprachige Gesellschaft für Psychotraumatologie, Psychisches Trauma-korperliches Leiden, Basel, Schweiz.

Language: German

Format: Conference

Abstract:
Es existieren kaum Untersuchungen mittels funktioneller Bildgebung, die den Effekt psychotherapeutischer Verfahren und deren Auswirkungen auf das Gehirn eruieren. Eye-Movement-Desensitization and Reprocessing (EMDR) ist ein anerkanntes Verfahren zur Behandlung der posttraumatischen Belastungsstörung, jedoch wurde noch keine fMRT-Studie zu diesem Verfahren veröffentlicht. Diese fMRT-Studie soll erste Hinweise auf die Auswirkungen einer EMDR-Therapie auf die Informationsverarbeitung einer Patientin mit einer posttraumatischen Belastungsstörung (PTBS) zeigen.

The fMRI study was at the ZI in a SIEMENS VISION 1.5 Tesla MR scanner with a 2D/EPI-Sequence (3.43 mm x 3:43 in plane Resolution, 24 layers, 4 mm per layer, 1 mm gap) and a Repetition time of 2.94 s made. It was her description of her of the accident at the moment of impact in a block design alternating with a baseline condition (only MRI noise) presented. Each 8x block was presented for 19.8 sec. After this there is a EMDRBehandlung (2h), where there were violent reactions of the patient. After a 20th Break was repeated the fMRI procedure. The Analysis was performed by BrainVoyager QX 1.9, with a t-test (fixed effect) with a threshold of q <0.5 (corrected) as was assumed significant.

Keywords: fMRI  Pilot Study  Poster  Posttraumatic Stress Disorder  PTSD  

Accuracy Verified: Yes

3. Landin-Romero, R., Novo, P., Vicens, V., McKenna, P. J., Santed, A., Pomarol-Clotet, E., Salgado-Pineda, P., Shapiro. F., & Amann, B. L. (2013, March). EMDR therapy modulates the default mode network in a subsyndromal, traumatized bipolar patient. Neuropsychobiology, 67(3), 181-184. doi:10.1159/000346654.

Language: English

Format: Journal

Abstract:
Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction. Copyright © 2013 S. Karger AG, Basel.

Keywords: Bipolar Disorder  Subsyndromal Affective Symptoms  

Accuracy Verified: Yes

4. Fay, D., Corrigan, F. Fisher, J., Galloway, J., & Mcafee, F. (2010, April). An fMRI study of the integration of “Becoming safely embodied” and EMDR techniques for the de-activation of fear motor neurocircuitry. Symposium presented at the 2nd Bi-Annual International European Society for Trauma and Dissociation, Belfast, Northern Ireland.

Language: English

Format: Conference

Abstract:
An fMRI Study of the Integration of “Becoming Safely Embodied” and EMDR Techniques for the De-Activation of Fear Motor Neurocircuitry Frank Corrigan, Consulting Psychiatist, Argyll & Bute Hospital, Lochgilphead, Argyll This panel discussion explores brain imaging results using BSE skills activating left anterior insula intensified with alternating bilateral stimulation (ABS) from Eye Movement Desensitisation and Reprocessing (Shapiro 1992). It suggests positive feelings associated with brain activations deactivate areas involved in motor responses to threat.

Keywords: Fear Motor Neurocircuitry  fMRI Study  

Accuracy Verified: Yes

5. Langwig, K. E. (2008, December). A functional magnetic resonance imaging study of the effects of eye movement desensitization and reprocessing therapy on post-traumatic stress disorder car accident patients: A pilot study. Union College, Schenectady, N.Y.

Language: English

Format: Dissertation/Thesis

Abstract:
Eye movement desensitization and reprocessing (EMDR) therapy is a novel therapy that has been effective in treating post-traumatic stress disorder (PTSD). Few studies have explored the neurological underpinnings of EMDR effectiveness. Utilizing a symptom provocation study design, this study assessed non-PTSD car accident patients. These pilot participants were scanned for comparison to PTSD patients and to explore the task design effectiveness for the future study of PTSD patients. One pilot participant exhibited activation in the left precuneus, and left medial temporal gyrus, and also in the left medial frontal gyrus. In PTSD patients the medial prefrontal cortex is often hypoactive, and inversely correlated with a hyperactive amygdala. The robust activation of medial frontal gyrus in the pilot subject with a corresponding inactivation of the amygdala indicates the participant's normal processing of the car accident trauma tic memories, and that task design and study parameters are being effectively implemented.

Keywords: Automobile Accidents  Car Accidents  fMRI  Pilot Study  Posttraumatic Stress Disorder  PTSD  

Accuracy Verified: Yes

6. Alexander, J. (April, 2013). Inside EMDR: A neurological perspective. The Neuropsychotherapist eMagazine. Retrieved from http://drjamespsychologist-com.webs.com/neurological-basis-of-emdr 4/8/2013.

Language: English

Format: Journal

Abstract:
While there is still some scepticism raised about the efficacy of Eye Movement Desensitization & Reprocessing (EMDR) within psychology (e.g Lilienfield & Arkowitz 2008), it is clear that this therapeutic approach has more than adequately fulfilled the requirements of an evidence based therapy. Most psychological and psychiatric associations around the world endorse EMDR as an evidence based approach to the treatment of psychological trauma and PTSD. This status was recently acknowledged by the World Health Organisation, which recommended this therapy as a first line treatment option for psychological trauma based on the evidence which has amassed testifying to its efficacy. Despite the advances in neuroscience which fMRI research has afforded in the last decade or so, little remains known of the neurological mechanisms of change associated with any psychotherapeutic approach. EMDR is no different, in that the precise mechanisms of change can only be speculated upon. Harvard neuroscientist Robert Stickgold (2002) provides a comprehensive example of these speculations. (He suggests that EMDR achieves its results by way of replicating the naturally occurring dream-based consolidation process via the eye movements which are common to both REM sleep and EMDR). However, little comment is currently available about EMDR in relation to recent findings concerning memory reconsolidation.

Keywords: Neuropsychotherapy  

Accuracy Verified: Yes

7. Rothbaum, B. (2008, November). Predictors of treatment response for EMDR and prolonged exposure. Symposium/panel conducted at the 24th annual meeting of the International Society for Traumatic Stress Studies, Chicago, IL.

Language: English

Format: Conference

Abstract:
Recent developments in PTSD treatment outcome research: Although cognitive behavior therapy is the treatment of choice for PTSD, there is a need to develop more effective treatments and to determine factors that influence treatment response. This symposium presents four studies that address treatment outcome research. The initial paper provides an overview of treatment predictors from two trials of cognitive processing therapy. The second paper reviews the differential responses to treatment of survivors of terrorist attacks and motor vehicle accidents. The third paper reviews predictors of outcome following EMDR and Prolonged Exposure. The fourth paper overviews a series of studies that have used structural and functional fMRI to identify the neural factors that predict response to CBT and also the impact of CBT on neural functioning.

Predictors of treatment response for EMDR and prolonged exposure: Predictors for response to treatment in a controlled study aimed to evaluate the relative efficacy of Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR) compared to a no-treatment wait-list control (WAIT) in the treatment of PTSD in adult female rape victims were examined. In this study, 74 participants with PTSD were randomly assigned to one of the three experimental conditions to achieve 20 completers per group. Independent Assessors blind to the treatment condition administered standard measures of PTSD and related symptoms. Improvement in PTSD, depression, dissociation, and state anxiety was significantly greater in both PE and EMDR group than the WAIT group. PE and EMDR did not differ significantly for change from baseline to either post-treatment or 6-month follow up measurement for any quantitative scale. EMDR subjects with 2 or more comorbid diagnoses, however, improved significantly less than all other active treatment subjects. At post-treatment and 6- months, 95% and 94% of PE subjects and 75% and 74% EMDR subjects no longer met DSM-IV PTSD criteria, respectively. At the 6-month follow-up assessment, 78% of those who received PE and 35% of those who received EMDR met criteria for good end state functioning (p=.017).

Keywords: Panel  Prolonged Exposure  Symposium  Treatment Response Predictors  

Accuracy Verified: Yes

8. Richardson, P., Williams, S. R., Hepenstall, S., Gregory, L., McKie, S., & Corrigan, F. (2009). A single-case fMRI study: EMDR treatment of a patient with posttraumatic stress disorder. Journal of EMDR Practice and Research, 3(1), 10-23. doi:10.1891/1933-3196.3.1.10.

Language: English

Format: Journal

Abstract:
This study assessed the effects of a session of eye movement desensitization and reprocessing (EMDR) with auditory alternating bilateral stimulation (ABS) using functional magnetic resonance imaging (fMRI) of brain activations. A case study was conducted with a female participant who was suffering from posttraumatic stress disorder following a severe assault. The fMRI scan began with safe-place imagery, for purposes of comparison, and then attention to the trauma memory without ABS. After this, ABS was provided as she began using EMDR procedures to process the traumatic memory. At postsession, the traumatic memory showed robust and significant changes on self-report measures. The initiation of the EMDR protocol with provision of ABS was associated with a marked change in brain activation within the prefrontal cortex demonstrating a ventromedial shift. The authors argue that the structure of the EMDR protocol encourages such a ventromedial activation, which is then intensified by ABS to overcome the block to information processing that has been preventing natural healing from occurring spontaneously.

Keywords: fMRI  Functional Magnetic Resonance Imaging  Posttraumatic Stress Disorder  PTSD  Single Case  

Accuracy Verified: Yes

9. Zantvoord, J. (2012, November). Trauma focused psychotherapies from a neurodevelopmental perspective: fMRI and physiological pilot outcome data from a RCT conducted in the Netherlands with children suffering from PTSD. Symposium conducted at the 28th annual meeting of the ISTSS, Los Angeles, CA.

Language: English

Format: Conference

Abstract:
Neurobiological treatment outcome studies in adults with PTSD have shown that successful treatment is associated with changes in activity of frontal brain areas and the amygdala, brain areas which are involved in fear conditioning and extinction. Frontal brain regions undergo considerable maturation during childhood and adolescence and only reach anatomical and functional maturity well within the third decade of life. In this light, results obtained in neurobiological studies in adults can’t be readily translated to children and adolescents. Neurobiological treatment outcome studies in children with PTSD are thus required, yet are almost nonexistent to date. Neurobiological treatment outcome studies addressing the mechanism involved in treatment response or non response can contribute to improve treatment strategies for non responders especially for treatment non responders and in time help clinicians to tailor treatment for individuals with PTSD. In this part of the symposium we will present treatment outcome data of our neurobiological pilot study conducted in children with PTSD in the Netherlands. Children aged 8 to 18 with PTSD were randomly assigned to receive either 8 sessions of manualized Trauma Focus cognitive behavioral therapy or EMDR. fMRI data of a working memory task with emotional distracters and physiological data obtained during script driven imagery will be presented. Treatment outcome results will be placed in a neurodevelopmental framework.

Keywords: Children, fMRI  Netherlands  Neurodevelopment  Pilot  Posttraumatic Stress Disorder  PTSD  Random Control Trial  RCT  

Accuracy Verified: Yes