Francine Shapiro Library ~ EMDR Bibliography

Francine Shapiro Library - EMDR Bibliography Links

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1. Oh, D. H., & Park, Y. C. (2010, July). Bilateral eye movement: Changes brain default network functions in EMDR treatment. Poster presented at the 1st EMDR Asia Conference, Bali, Indonesia.

Language: English

Format: Conference

Abstract:
Introduction: The aim of this study was to clarify the effect of bilateral eye movement as one of the important therapeutic components through EEG analysis. We examined differences between pre-bilateral eye movement and post-bilateral eye movement of normal healthy volunteers in scalp recorded EEGs in two different ways. First, we used qEEG to examine differences in specific band frequencies after bilateral eye movement. Secondly, we utilized low-resolution electromagnetic tomography (LORETA) source imaging (Pascual-Marqui et al., 1994) to explore the underlying neural generators of changed EEG activity. Methods:32 college students participated in the study. EEG was recorded continuously during the experiment. All participants experienced 3 blocks: 1) pre-experiment, eye-closed EEG in resting state, 2) stimuli condition (either eye movement or fixation) and 3) post-experiment, eye-closed EEG in resting state. 32-channel, eyes-closed EEG (30 artifactfree s/subject) was analyzed (source localization using FFT approximation and LORETA). Results: We demonstrated different functional connectivity patterns of the precuneus/posterior cingulate cortex (Brodmann area 23, 31) between bilateral eye movement and eye fixation phase. Conclusion: These results provided evidence to support that the bilateral eye movements in EMDR procedure gives rise to the changes of ‘brain default network’, accompanied by the alteration of regional brain electrical activity.

Keywords: Eye Movements Poster

Accuracy Verified: Yes

2. Solomon, E. P., & Heide, K. M. (2005, January). The biology of trauma: Implications for treatment. Journal of Interpersonal Violence, 20(1), 51-60. doi:10.1177/0886260504268119.

Language: English

Format: Journal

Abstract:
During the past 20 years, the development of brain imaging techniques and new biochemical approaches has led to increased understanding of the biological effects of psychological trauma. New hypotheses have been generated about brain development and the roots of antisocial behavior. We now understand that psychological trauma disrupts homeostasis and can cause both short and long-term effects on many organs and systems of the body. Our expanding knowledge of the effects of trauma on the body has inspired new approaches to treating trauma survivors. Biologically informed therapy addresses the physiological effects of trauma, as well as cognitive distortions and maladaptive behaviors. The authors suggest that the most effective therapeutic innovation during the past 20 years for treating trauma survivors has been Eye Movement Desensitization and Reprocessing (EMDR), a therapeutic approach that focuses on resolving trauma using a combination of top-down (cognitive) and bottom-up (affect/body) processing. [Author Abstract]

Keywords: Adolescents Child Abuse Children Criminal Behavior Forensic Evaluation Literature Review Neglect Neuroendocrinology Neurophysiology Posttraumatic Stress Disorder PTSD Survivors

Accuracy Verified: Yes

3. Pagani, M., Salmaso, D., Looi, J., & Hogberg, G. (2008, June). Brain functional and volumetric analyses post traumatic stress disorder treated by EMDR. Presentation at the annual meeting of the EMDR Europe Association, London, England.

Language: English

Format: Conference

Abstract:
Neuro-imaging investigations in PTSD have reported findings for either functional or structural modifications. Only two studies have investigated the changes in cerebral blood flow (CBF) following EMDR therapy and one single-patient study recently reported EMDR-related structural changes. The aim of this study was to analyse the structural and functional changes occurring in brain regions implicated in the patho-physiology of PTSD along with the impact on CBF and volumetric data after EMDR treatment. Thirty six train drivers having being exposed to traumatic experiences at work were assigned to different two groups: symptomatic (S, n=17) or nonsymptomatic (NS, n=19), according to PTSD diagnosis. SPECT, following administration of an individualised 35 trauma script, and MRI were performed and EMDR therapy was administered to S. According to EMDR outcome S were further subdivided in responders (R, n=11) and non-responders (NS, n=5). One patient was not treated. CBF and volumetric analyses were performed on temporal lobes, hippocampi and nuclei caudati. ANOVA showed a significantly higher CBF distribution in the left temporal lobe of S as compared to NS and the right nc.caudatus was significantly larger in S. The R group had larger hippocampi and nc.caudati as compared to NR and the size of hippocampi correctly identified 81% of R and NR. The increased left temporal lobe CBF distribution among symptomatic PTSD subjects may reflect the affective significance of higher effort in emotional episodic memory stimulation among symptomatic individuals. Hippocampi volume as measured before EMDR was shown to predict with high accuracy the therapy outcome.

Keywords: Posttraumatic Stress Disorder PSTD

Accuracy Verified: Yes

4. Bossini, L. (2008, 26-28 Settembre). Brain imaging strutturale e PTSD: Danno cerebrale ed effetto della terapia con EMDR [Brain imaging structural and PTSD: Brain damage and effect of treatment with EMDR]. In T. Farma (Chair), Simposio Il modello psicotraumatologico: Un ponte TRA indicatori neurobiologici e Psicoterapia. VII Congresso SPR Italia, Modena.

Language: Italian

Format: Conference

Keywords: Brain Imaging Symposium

Accuracy Verified: Yes

5. Lendl, J. (2002, June). Brain performance and possible EMDR intervention. Presentation at the annual meeting of the EMDR International Association, San Diego, CA.

Language: English

Format: Conference

Abstract:
New brain imaging technologies are giving a clearer picture of how memories are stored and how effective treatment may alter brain function. Neuroimaging researchers Bessel van der Kolk and Daniel Amen are investigating EMDR treatment effects. Van der Kolk is studying how traumatic memories differ from memories of ordinary events, while Amen concentrates on evaluating difficult psychiatric cases, ADD, head trauma, memory problems, dementia, aggression, and exposure to toxic substances. This workhop will focus on Amen's research regarding frequently found patterns of brain performance, including specific area functions and problems from a clinician's view. Significant attention will be devoted to integrating EMDR with the Amen multi-discipline intervention approach for problem brian areas.

Keywords: Amen Brain Performance van de Kolk

Accuracy Verified: Yes

6. Lendl, J. (2001, June). Brain performance and possible EMDR intervention. Presentation at the annual meeting of the EMDR International Association, Austin, TX.

Language: English

Format: Conference

Abstract:
Participants will: 1) be able to identify functions and problems of several brain areas; 2) be able to identify sepcific targets for suggested EMDR interventions; and 3) learn when to refer for possible brain scan.

Keywords: Brain Performance Brain Scan SPECT

Accuracy Verified: Yes

7. Haour, F. (2009, June). Brain source imaging of the alpha rhythm in PTSD patients using the MEG technique. In K. Zaal (Chair), Research). Symposium conducted at the annual meeting of the EMDR Europe Association, Amsterdam, the Netherlands.

Language: English

Format: Conference

Abstract:
In anxiety disorders, such as PTSD, brain imaging has demonstrated local modifications of functional activities using various techniques. In the present study the direct neuronal activities were measured in delta, theta and beta frequencies, using Magnetoencephalagraphy (MEG) which provides very fast temporal response. The technique is neither invasive nor stressful for the patients. Nineteen female volunteers with DSM-IV PTSD were included in the study. The protocol was a script-driven imagery provocation test, achieved with the patients sitting in the MEG apparatus. The scenarios, specific for ach patient, were composed of 4 active conditions: neutral image (N) traumatic memory (T), traumatic memory suppression (TS) and positive image (P) corresponding to 3 minutes where the patient had to imagine the corresponding sequence with eyes closed Measures of heat rate and subjective disturbance (SUD) were measured during the recoding. The MEG data were analysed in the source domain using a spatial filtering approach. Measurement of electrophysiological waves of various rhythms: delta: 1-4 Hetz (Hz), theta: 4.8-5.8 Hz, alpha: 8-12 Hz and beta: 12-25 Hz was obtained. Anatomical information was from MRI imaging. Signal of activation during trauma recall (T-N) were limited to the delta and theta waves and mainly found in the left hemisphere (visual, orbitofrontal and dorsolateral prefrontal and temporal gyrus (BA 8-9-10-11, 18-19, 22, 28) and in the right supra marginal gyrus (Wernicke BA 40). Signal of inhibition during trauma recall (T-N) were found mainly in the left hemisphere, in the delta, alpha and beta waves (visual, orbitofrontal, dorsolateral prefrontal and temporal gyrus (BA 8-9-10-11, 18-18, 22, 28), cingular cortex (BA 23-24, 31, 32), insula (BA 13) and Broca visual cortex (BA 18-19, 43-44). In conclusion trauma recall mainly induces a hypoactivation in the ventromedial prefrontal cortex and in the cingular cortices, structures linked to the experience and regulation of emotions.

Keywords: Alpha Rhythm Brain Imaging MEG Technique Posttraumatic Stress Disorder PTSD Research Symposium

Accuracy Verified: Yes

8. Haour, F. (2010, June). Brain source imaging using magnetoencephalography (MEG): Modifications in various rhythms during memory recall, in PTSD patients. In Research. Symposium conducted at the annual meeting of the EMDR Europe Association, Hamburg, Germany.

Language: English

Format: Conference

Keywords: Magnetoencephalography MEG Memory Recall Posttraumatic Stress Disorder PTSD Research Rhythms Symposium

Accuracy Verified: Yes

9. Snyker, E. (2003, May). Brain SPECT imaging and EMDR. Symposium conducted at the annual meeting of the EMDR Europe Association, Rome, Italy.

Language: English

Format: Conference

Keywords: Brain SPECT Imaging Symposium

Accuracy Verified: Yes

10. Amen, D. G. (2003, September). Brain SPECT imaging in PTSD and EMDR. Preconference presentation at the annual meeting of the EMDR International Association, Denver, CO.

Language: English

Format: Conference

Abstract:
Brain SPECT provides a window into brain activity and helps us understand the underlying physiology of many neurological and psychiatric illnesses. Specific psychological and medical treatments enhance or change our brain function. In this lecture, Dr. Amen will describe his extensive clinical experience and research into postraumatic stress disorder and EMDR. He has been involved in performing before and after brain SPECT scans for PTSD patients for several years and recently completed a formal research project with Karen Lansing on PTSD and EMDR. The results of this study will also be discussed.

Keywords: SPECT Brain

Accuracy Verified: Yes

11. Amen, D. G. (1999, June). Change your brain, change your life (EMDR not the focus). Presentation at the annual meeting of the EMDR International Association, Las Vegas, NV.

Language: English

Format: Conference

Abstract:
Participants will: 1) learn the functions the problems associated with five different brain systems; 2) learn the impact of head injuries on psychological behavior; and 3) develop three psychological strategies for enhancing each different brain system.

Keywords: Brain Brain Systems Head Injuries SPECT

Accuracy Verified: Yes

12. Amen, D. G. (2003, September). Change your brain, change your life: Breakthrough information on seeing and healing the brain. Presentation at the annual meeting of the EMDR International Association, Denver, CO.

Language: English

Format: Conference

Abstract:
Utilizing the latest, most sophistcated brain imaging technology in medicine, physician and clinical neuroscientist Daniel Amen will give you an intimate look into a "working brain." Based on his brain imaging work with over 16,000 brain SPECT studies, Dr.Amen will teach you what specific parts of the brain do, and graphically show what happens when things go wrong, illustrated by many case stories and a number of the actual brain images. He will correlate different brain patterns with specific feelings and behaviors, such as moodiness, irritability, conflict avoidance, worrying and temper outbursts, along with certain common psychiatric disorders such as depression, attenton deficit disorder, anxiety, and substance abuse. In addition, there will be prescriptions for healing each part of the brain, including cognitive, behavioral, nutritional and medicinal strategies.

Keywords: Brain SPECT

Accuracy Verified: Yes

13. Oh, D., & Choi, J. (2004). Changes in the regional cerebral perfusion after EMDR: A SPECT study of two cases. Journal of the Korean Society of Biological Psychiatry, 11(2), 173-180.

Language: Korean

Format: Journal

Abstract:
Over the last decade, EMDR(Eye Movement Desensitization and Reprocessing) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, neurobiological mechanism of EMDR has not been well understood. Authors report SPECT findings of two patients of PTSD before and after EMDR.Brain 99mTc-ECD-SPECT was performed before and after EMDR treatment. To evaluate the significance of changes in the regional cerebral perfusion, t-test was conducted on the resulting images using SPM99 . In addition, clinical scales(CAPS, CGI, STAI) were employed to asses the changes in the clinical symptoms of the patients. After EMDR treatment, each showed significant improvement in clinical symptoms. The cerebral perfusion increased in bilateral dorsolateral prefrontal cortex, and decreased in the temporal association cortex. The differences in the cerebral perfusion between patients after treatment and normal controls decreased. These changes appeared mainly in the limbic area the and the prefrontal cortex.These results suggest that EMDR may show the therapeutic effect through 1) improvement in the emotional control by increased activity in the prefrontal cortex, 2) inhibited hyperstimuli on amygdala by deactivation of the association cortex, 3) inhibition on past trauma related memory, and 4) keeping the functional balance between the limbic area and the prefrontal cortex. This case report needs further replication from studies with larger sample. [Author Abstract]

Keywords: Brain Imagining Adults Females Koreans Motor Vehicle Accidents Neurophysiology Posttraumatic Stress Disorder Psychiatric Inpatients PTSD: Rape SPECT Survivors Treatment Effectiveness

Accuracy Verified: Yes

14. Oh, D. H., & Choi, J. (2007). Changes in the regional cerebral perfusion after eye movement desensitization and reprocessing: A SPECT study of two cases. Journal of EMDR Practice and Research, 1(1), 24-30. doi:10.1891/1933-3196.1.1.24.

Language: English

Format: Journal

Abstract:
Eye movement desensitization and reprocessing (EMDR) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, the neurobiological mechanism of EMDR has not been well understood. This study reports changes in the resting regional cerebral blood flow after successful EMDR treatment in 2 patients with PTSD. Brain 99mTc-ECD-SPECT (Technetium 99m-ethyl cysteinate dimmer-single photon emission computerized tomography) was performed before and after EMDR, and, in addition, a pre- and posttreatment comparison was made with 10 non-PTSD participants as a control group. After EMDR, cerebral perfusion increased in bilateral dorsolateral prefrontal cortex and decreased in the temporal association cortex. The differences between participants and normal controls also decreased. Changes appeared mainly in the limbic area and the prefrontal cortex. These results are in line with current understanding of neurobiology of PTSD. EMDR treatment appears to reverse the functional imbalance between the limbic area and the prefrontal cortex. [Author Abstract]

Keywords: Adults Brain Imaging Females Koreans Motor Traffic Accidents Neuroimaging Neurophysiology Posttraumatic Stress Disorder Psychiatric Inpatients PTSD Rape RCBF Regional Cerebral Blood Flow Single Photon Emission Computerized Tomography Survivors Treatment Effectiveness

Accuracy Verified: Yes

15. Oh, D. H., & Choi, J. (2004, October). Changes in the regional cerebral perfusion assessed with 99mTc-ECD-SPECT after eye movement desensitization and reprocessing treatment. Poster spresented at the annual meeting Korean Neuropsychiatric Association, Seoul, Korea.

Language: Korean

Format: Conference

Keywords: Poster Regional Cerebral Perfusion SPECT

Accuracy Verified: Yes

16. Landin-Romero, R., Novo, P., Santed, A., Vicens, V., McKenna, P. J., Pomarol-Clotet, E., Salgado-Pineda, P., Shapiro, F., & Amann, B. (2012, June). Clinical remission and functional modulation of the default mode network in a subsyndromal, traumatized bipolar patient after EMDR psychotherapy. Poster presented at the annual meeting of EMDR Europe, Madrid, Spain .

Language: English

Format: Conference

Abstract: Purpose of the study: Some patients with bipolar disorder do not show complete remission between episodes, but continue to exhibit subsyndromal mood symptoms [1]. One factor related may be comorbid posttraumatic stress disorder (PTSD), which has been found to be present in 16% to 39% of patients with bipolar disorder [2]. We describe the first case of an unstable bipolar II patient with history of various traumas that received Eye Movement Desensitization and Reprocessing (EMDR) psychotherapy and also underwent functional magnetic resonance imaging (fMRI) before and after the EMDR treatment to explore its effect on the brain’s neural networks.

Keywords: Bipolar Disorder

Accuracy Verified: Yes

17. Amen, D. G. (1997, July). A clinician’s guide to understanding and treating ADD. Presentation at the annual meeting of the EMDR International Association, San Francisco, CA.

Language: English

Format: Conference

Abstract:
Focuses primarily on ADD not EMDR.

Keywords: ADD Attention Deficit Disorder Brain SPECT

Accuracy Verified: Yes

18. Pagani, M., Högberg, G., Fernandez, I., & Siracusano, A. (2013). Correlates of EMDR therapy in functional and structural neuroimaging: A critical summary of recent findings. Journal of EMDR Practice and Research, 7(1), 29-38. doi:10.1891/1933-3196.7.1.29.

Language: English

Format: Journal

Abstract:
Neuroimaging investigations of the effects of psychotherapies treating posttraumatic stress disorder (PTSD), including eye movement desensitization and reprocessing (EMDR), have reported findings consistent with modifications in cerebral blood flow (CBF; single photon emission computed tomography [SPECT]), in neuronal volume and density (magnetic resonance imaging [MRI]), and more recently in brain electric signal (electroencephalography [EEG]). Additionally in the recent past, EMDR- related neurobiological changes were monitored by EEG during therapy itself and showed a shift of the maximal activation from emotional limbic to cortical cognitive brain regions. This was the first time in which neurobiological changes occurring during any psychotherapy session have been reported, making EMDR the first psychotherapy with a proven neurobiological effect. The purpose of this article was to review the results of functional and structural changes taking place at PTSD treatment and presented during the period of 1999–2012 by various research groups. The reported pathophysiological changes are presented by neuropsychological technique and implemented methodology and critically analyzed.

Keywords: EEG Limbic System MRI Neurobiology SPECT

Accuracy Verified: Yes

19. Hopper, J., Spinazzola, J., Blaustein, M., Yehuda, R., van der Kolk, B. A., & Simpson, W. (2003, October-November). Differential biological outcomes of EMDR and fluoxetine for PTSD. In B. A. van der Kolk (Chair), Treatment outcome studies of PTSD. Symposium conducted at the 19th annual meeting of the International Society for Traumatic Stress Studies, Chicago, IL.

Language: English

Format: Conference

Abstract:
Treatment Outcome Studies of PTSD: This symposium presents three large carefully controlled treatment outcome studies using four different treatment modalities (CBT, EMDR, psychopharmacology and Cognitive Processing) and presents data on comparative efficacy, treatment responsiveness and resistance, effects on comorbidity, quality of life, and biological changes that accompany symptom improvement.

Differential Biological Outcomes of EMDR and Fluoxetine for PTSD: Two major developments in PTSD research have been the development of effective treatments and the delineation of pathophysiology. While major gains have been made in both of these areas, they have occurred in parallel. There is a need for investigations of possible differential effects of different treatment modalities on biological aspects of PTSD. In this randomized controlled trial (N = 105), we compared the exposure treatment Eye Movement Desensitization and Reprocessing, the serotonergic reuptake inhibitor fluoxetine, and pill placebo for their effects on both PTSD symptoms and biological parameters. The outcome measures were severity of reexperiencing, avoidant/numbing, and hyperarousal symptoms; psychophysiological reactivity to script-driven imagery; basal salivary cortisol and dexamethasone suppression test (DST). At pre-treatment, post-treatment and 3-month follow-up, saliva samples were acquired at 8 a.m., 11 p.m. (immediately followed by dexamethasone) and 8 a.m.. Participants also underwent a script-driven imagery protocol utilizing four 30s scripts, each followed by a 60s script imaging period and 2 minute recovery periods (fixed order: neutral, trauma, neutral, trauma). Preliminary analyses partially support hypothesizes concerning differential efficacies of pharmacological and psychological treatments on different symptom clusters and biological markers of the disorder, at post-treatment and 3- month follow-up. Potential implications for treatment and future research will be discussed.

Keywords: Fluoxetine Posttraumatic Stress Disorder PTSD Symposium

Accuracy Verified: Yes

20. Propper, R. E., Pierce, J., Geisler, M. W., Christman, S. D., & Bellorado, N. (2007, September). Effect of bilateral eye movements on frontal interhemispheric gamma EEG coherence: Implications for EMDR therapy. Journal of Nervous Mental Disorders, 195(9), 785-788. doi:10.1097/NMD.0b013e318142cf73.

Language: English

Format: Journal

Abstract:
The use of bilateral eye movements (EMs) is an important component of Eye Movement Desensitization and Reprocessing (EMDR) therapy for PTSD. The neural mechanisms underlying EMDR remain unclear. However, prior behavioral work looking at the effects of bilateral EMs on the retrieval of episodic memories suggests that the EMs enhance interhemispheric interaction. The present study examined the effects of the EMs used in EMDR on interhemispheric electroencephalogram coherence. Relative to noneye-movement controls, engaging in bilateral EMs led to decreased interhemispheric gamma electroencephalogram coherence. Implications for future work on EMDR and episodic memory are discussed. [Author Abstract]

Keywords: Adults Americans Brain Imaging Bilateral Eye Movements College Students Empirical Study Neurophysiology Posttraumatic Stress Disorder PTSD Quantitative Study

Accuracy Verified: Yes

21. Goodwin, D., Banner, L., & Hayward, R. (1995, June). Effects of EMDR in treating erectile dysfunction measured by magnetic resonance imaging. Symposium conducted at the EMDR Network Conference, Santa Monica, CA.

Language: English

Format: Conference

Abstract:
The experimenters seek to determine whether the reported anxiety-relieving effects of (EMDR) can be effectively applied to patients reporting erectile dysfunction and whether the expected changes in levels of anxiety can be measured as a function of changes in brain function observed through MRI tracings. The MRI is well suited to reflect hypothesized changes in the lowering of sympathetic arousal and the increasing of parasympathetic arousal as a response to EMDR procedures. This investigation, using the MRI brain scanning procedures was followed in stages of (1) establishing criteria for the radiological determination of characteristics of brain function measured with the MRI that descriminate between levels of experimentally induced anxiety and (2) conducting an experimental investigation of the application of EMDR while patients are undergoing the MRI scanning protocol. Psychological measures include the Personality Assessment Inventory(PAI) to screen for psychotherapy of subjects, the Impact of Events Scale(IOE), and the State-Trait Anxiety Inventory(STAI). Correlations between these scales and ratings of physiological changes are reported.

Keywords: Erectile Dysfunction MRI Scanning Protocol Symposium

Accuracy Verified: Yes

22. Pagani, M., Hogberg, G., Salmaso, D, Tarnell, B., Nardo, D., Sundin, Ö., Jonsson, C., Soares, J., Aberg-Wistedt, A., Jacobsson, H., Larsson, S.A., Hällström, T. (2007, October). Effects of EMDR psychotherapy on 99mTc-HMPAO distribution in occupation-related post-traumatic stress disorder. Nuclear Medicine Communications, 28(10), 757-765. doi:10.1097/MNM.0b013e3282742035.

Language: English

Format: Journal

Abstract:
Background: Post-traumatic stress disorder (PTSD) is a derangement of mood control with involuntary, emotionally fraught recollections that may follow deep psychological trauma in susceptible individuals. This condition is treated with pharmacological and/or cognitive therapies as well as psychotherapy with eye movement desensitization and reprocessing (EMDR). However, only a very limited number of studies have been published dealing with work-related PTSD, and investigations on the effect of treatment on cerebral blood flow represent an even smaller number. Aim: To investigate the short-term outcome of occupation-related PTSD after EMDR therapy by 99mTc-HMPAO SPECT. Method: Fifteen patients, either train drivers suffering from PTSD after having been unintentionally responsible for a person-under-train accident or employees assaulted in the course of duty, were recruited for the study. 99mTc-HMPAO SPECT was performed on these patients both before and after EMDR therapy while they listened to a script portraying the traumatic event. Tracer distribution analysis was then carried out at volume of interest (VOI) level using a three-dimensional standardized brain atlas, and at voxel level by SPM. The CBF data of the 15 patients were compared before and after treatment as well as with those of a group of 27 controls who had been exposed to the same psychological traumas without developing PTSD. Results: At VOI analysis significant CBF distribution differences were found between controls and patients before and after treatment (P=0.023 and P=0.0039, respectively). Eleven of the 15 patients responded to treatment, i.e., following EMDR they no longer fulfilled the DSM-IV criteria for PTSD. When comparing only the eleven responders with the controls, the significant group difference found before EMDR (P=0.019) disappeared after treatment. Responders and non-responders showed after therapy significant regional differences in frontal, parieto-occipital and visual cortex and in hippocampus. SPM analysis showed significant uptake differences between patients and controls in the orbitofrontal cortex (Brodmann 11) and the temporal pole (Brodmann 38) both before and after treatment. A significant tracer distribution difference present before treatment in the uncus (Brodmann 36) disappeared after treatment, while a significant difference appeared in the lateral temporal lobe (Brodmann 21). Conclusion: Significant 99mTc-HMPAO uptake regional differences were found, mainly in the peri-limbic cortex, between PTSD patients and controls exposed to trauma but not developing PTSD. Tracer uptake differences between responders and patients not responding to EMDR were found after treatment suggesting a trend towards normalization of tracer distribution after successful therapy. These findings in occupational related PTSD are consistent with previously described effects of psychotherapy on anxiety disorders. [PubMed]

Keywords: 99mTc-HMPAO Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

23. Pagani, M., Hogberg, G., Salmaso, D., Nardo, D., Jonsson, C., Danielsson, A.M., Engelin, L., Jacobsson, H., Larsson, S. A., Hallstrom, T., & Sundin, Ö. (2006, September). Effects of EMDR therapy on 99mTc-HMPAO distribution in Post-traumatic stress disorder. Presentation at the European Assocation of Nuclear Medicine Congress, Athens, Greece. European Journal of Nuclear Medical and Molecular Imaging, 33, S169.

Language: English

Format: Conference

Abstract:
Background Post-traumatic stress disorder (PTSD) is a derangement of mood control with emotional trauma recollections that may follow psychological trauma. It is treated with pharmacological and cognitive therapies as well as with eye movement desensitization and reprocessing (EMDR). However, a limited number of studies have been published dealing with job related PTSD, and an even smaller number have assessed the effects of treatment on CBF. The aim of this study was to investigate the short term outcome of occupation based PTSD after EMDR therapy by 99mTc-HMPAO SPECT. Methods Fifteen patients suffering PTSD after having experienced a person under train accident or having been assaulted at work were included into the study. 99mTc-HMPAO SPECT was performed before and after EMDR therapy while listening to a script portraying the traumatic event. Tracer distribution analysis was performed at VOI level using a 3D standardised brain atlas and at cluster of voxel level by SPM and was subjected to an analysis of treatment as well as contrasted to a group of 27 subjects exposed to the same psychological trauma and not developing PTSD. Results Eleven of 15 patients responded to treatment, i.e. they did no longer fulfil the DSM-IV criteria for PTSD after EMDR. Overall VOI analysis showed significant differences between, both before and after treatment conditions and controls (p<0.05) but no effect of period, i.e. treatment. However, when contrasting responders to controls the significant group difference present after treatment disappeared, indicating a normalization effect due to successful EMDR treatment. SPM analysis showed significant uptake differences in orbitofrontal cortex (Brodmann 11) and temporal pole (Brodmann 38) before as well as after treatment as compared to controls. A significant tracer uptake group difference present before treatment in uncus (Brodmann 36) disappeared after treatment while a significant difference appeared in lateral temporal lobe (Brodmann 21). No tracer uptake differences were found by SPM as an effect of treatment, nor between the 11 responders and controls. Conclusion Significant 99mTc-HMPAO uptake differences, mainly in peri-limbic cortex, between PTSD patients investigated before and after EMDR and subject exposed to trauma not developing PTSD were found. Differences between the tracer distribution in patients before and after therapy were not significant neither at SPM nor at VOI analyses but the latter showed at group level an effect of symptom remission on tracer distribution. The findings underscore the validity of psychotherapy in anxiety disorders and confirm the efficacy of SPECT in psychiatry. [EANM]

Keywords: 99mTc-HMPAO Distribution Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

24. Pagani, M., Hogberg, G., Salmaso, D., Nardo, D., Jonsson, C., Danielsson, A. M., Engelin, L., Jacobsson, H., Larsson, S. A., Hallstrom, T., & Sundin, Ö. (2006, September-October). Effects of EMDR therapy on 99mTc-HMPAO distribution in Post-traumatic Stress Disorder. Presentation at the European Assocation of Nuclear Medicine Congress, Athens, Greece.

Language: English

Format: Conference

Keywords: 99mTc-HMPAO Distribution Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

25. Kavanaugh, D. J., Freese, S., Andrade, J., & May, J. (2001). Effects of visuospatial tasks on desensitization to emotive memories. British Journal of Clinical Psychology, 40(3), 267-280. doi:10.1348/014466501163689.

Language: English

Format: Journal

Abstract:
Objectives. Intrusive memories of extreme trauma can disrupt a stepwise approach to imaginal exposure. Concurrent tasks that load the visuospatial sketchpad (VSSP) of working memory reduce the vividness of recalled images. This study tested whether relief of distress from competing VSSP tasks during imaginal exposure is at the cost of impaired desensitization. Design. This study examined repeated exposure to emotive memories using 18 unselected undergraduates and a within-subjects design with three exposure conditions (Eye Movement, Visual Noise, Exposure Alone) in random, counterbalanced order. Method. At baseline, participants recalled positive and negative experiences, and rated the vividness and emotiveness of each image. A different positive and negative recollection was then used for each condition. Vividness and emotiveness were rated after each of eight exposure trials. At a post-exposure session 1 week later, participants rated each image without any concurrent task. Results. Consistent with previous research, vividness and distress during imaging were lower during Eye Movements than in Exposure Alone, with passive visual interference giving intermediate results. A reduction in emotional responses from Baseline to Post was of similar size for the three conditions. Conclusion. Visuospatial tasks may offer a temporary response aid for imaginal exposure without affecting desensitization.

Keywords: Emotive Memories Eye Movement Imaginal Expsoure Visio-Spatial

Accuracy Verified: Yes

26. Kavanagh, D. J., Freese, S., Andrade, J., & May, J. (2001, September). Effects of visuospatial tasks on desensitization to emotive memories. British Journal of Clinical Psychology, 40(3), 267–280. doi:10.1348/014466501163689.

Language: English

Format: Journal

Abstract:
Objective. Intrusive memories of extreme trauma can disrupt a stepwise approach to imaginal exposure. Concurrent tasks that load the visuospatial sketchpad (VSSP) of working memory reduce the vividness of recalled images. This study tested whether relief of distress from competing VSSP tasks during imaginal exposure is at the cost of impaired desensitization. Design. This study examined repeated exposure to emotive memories using 18 unselected undergraduates and a within-subjects design with three exposure conditions (Eye Movement, Visual Noise, Exposure Alone) in random, counterbalanced order. Method. At baseline, participants recalled positive and negative experiences, and rated the vividness and emotiveness of each image. A different positive and negative recollection was then used for each condition. Vividness and emotiveness were rated after each of eight exposure trials. At a post-exposure session 1 week later, participants rated each image without any concurrent task. Results. Consistent with previous research, vividness and distress during imaging were lower during Eye Movements than in Exposure Alone, with passive visual interference giving intermediate results. A reduction in emotional responses from Baseline to Post was of similar size for the three conditions. Conclusion. Visuospatial tasks may offer a temporary response aid for imaginal exposure without affecting desensitization.

Keywords: Emotive Memories Visuospatial Tasks

Accuracy Verified: Yes

27. de Roos, C., & Went, M. (2012, June). EMDR as trauma treatment for infants (0-4 years) [EMDR como tratamiento para el trauma en niños pequeños (0-‐4 años)]. Presentation at the annual meeting of the EMDR Europe Association, Madrid, Spain.

Language: English

Format: Conference

Abstract:
In our therapeutic EMDR work with deaf and hard of hearing clients, we are forced to strongly focus on the visual world. But focus on visual aspects is not only necessary with this client group! When working with pre-‐verbal trauma, with children or adults who are (not yet) fluent in their native speech or when we use EMDR with clients that use a second language, we will have to use alternatives to spoken languages. When used correctly, visual input can enrich and enable the EMDR process greatly. In this presentation we invite visitors to explore the visual aspects and possibilities of the EMDR process with us. Visitors will feel more adequate in using mimic, visual and imaging techniques with their clients. Video material will enrich our presentation. We will present in English and Dutch sign language. Our interpreter will translate the Dutch sign language in spoken English.

Los infantes (0-‐4 años) pueden ser expuestos a diversos tipos de eventos traumáticos, por ejemplo procedimientos médicos intrusivos, abuso sexual y otras formas de violencia física o emocional, y pueden desarrollar síntomas de estrés post-‐traumático. Por otro lado, no es fácil determinar si están traumatizados desde esa edad, la mayoría de los niños no son capaces de comunicar verbalmente sus experiencias. En la mayoría de los ejemplo, son los padres los que notan un cambio en el comportamiento de su hijo y van en busca de ayuda. Los terapeutas junto con los padres y usando la información disponible del propio niño, desarrollan una hipótesis sobre el origen de los síntomas. Si existen indicios de que los síntomas actuales están relacionados con un evento traumático sin procesar, EMDR es idóneo. El método de Cuenta-‐cuentos de Lovett puede ser usado para este propósito. Se necesita prestar una especial atención a la interacción entre los padres y el niño. Los padres pueden encontrar difícil apoyar a su hijo o reaccionar adecuadamente al comportamiento del niño cuando se sienten ansiosos o culpables de este evento traumático. Este tipo de cuestiones deben ser tomadas en cuenta ya que pueden agravar los síntomas ya existentes en el niño Después de una pequeña introducción teórica, numerosos casos serán mostrados en video. Mostramos como los recuerdos traumáticos sin procesar en infantes pueden ser activados y procesados. En uno de los casos EMDR se combinará con elementos de la terapia orientada a padres. Conceptos sobre el apego y sus efectos en el EMDR serán mostrados.

Keywords: Infants

Accuracy Verified: Yes

28. Tinker, R., & Wilson, S. (2011, August). EMDR cases on the cutting edge of neuroscience. Presentation at the annual meeting of the EMDR International Association, Orange County, CA.

Language: English

Format: Conference

Abstract:
In EMDR, we see results that inform us about neuroplastic abilities of the brain, that go beyond occurrences in conventional psychotherapy. For example, in EMDR, we sometimes see the emergence and resolution of stigmata; the elimination of phantom limb pain; resolution of trauma with very young children; the resolution of pre-verbal trauma in children and adults. Through case presentations, videos, photographs, and brain imaging, this offering will consider some neuroscientific implications, based on detailed analyses of several cases of adults and children. A history of stigmata with be covered, along with associations to Psychogenic Purpura.

Keywords: Neuroscience

Accuracy Verified: Yes

29. Landin-Romero, R., Novo, P., Vicens, V., McKenna, P. J., Santed, A., Pomarol-Clotet, E., Salgado-Pineda, P., Shapiro. F., & Amann, B. L. (2013, March). EMDR therapy modulates the default mode network in a subsyndromal, traumatized bipolar patient. Neuropsychobiology, 67(3), 181-184. doi:10.1159/000346654.

Language: English

Format: Journal

Abstract:
Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction. Copyright © 2013 S. Karger AG, Basel.

Keywords: Bipolar Disorder Subsyndromal Affective Symptoms

Accuracy Verified: Yes

30. Landin-Romero, R., Novo, P., Vicens, V., McKenna, P. J., Santed, A., Pomarol-Clotet, E., Salgado-Pineda, P., Shapiro. F., & Amann, B. L. (2013, March). EMDR therapy modulates the default mode network in a subsyndromal, traumatized bipolar patient. Neuropsychobiology, 67(3), 181-184. doi:10.1159/000346654.

Language: English

Format: Journal

Keywords: Bipolar Disorder Subsyndromal Affective Symptoms

Accuracy Verified: Yes

31. Landin-Romero, R., Novo, P., Vicens, V., McKenna, P. J., Santed, A., Pomarol-Clotet, E., Salgado-Pineda, P., Shapiro. F., & Amann, B. L. (2013, March). EMDR therapy modulates the default mode network in a subsyndromal, traumatized bipolar patient. Neuropsychobiology, 67(3), 181-184. doi:10.1159/000346654.

Language: English

Format: Journal

Keywords: Bipolar Disorder Subsyndromal Affective Symptoms

Accuracy Verified: Yes

32. Wilson, S., Tinker, R., Becker, L., Hofmann, A., & Cole, J. W. (2000, September). EMDR treatment of phantom limb pain with brain imaging (MEG). Presentation at the annual meeting of the EMDR International Association, Toronto, Ontario Canada.

Language: English

Format: Conference

Abstract:
Participants will be able to: 1) decribe phantom limb pain and its parameters; 2) understand the current use of MEG technology with respect to phantom limb pain; and 3) understand and describe EMDR treatment protocol for phantom limb pain.

Keywords: Brain Imaging MEG Phantom Limb

Accuracy Verified: Yes

33. Corrigan, F. M. (2005, June). Emoting mindfullness drives reprocessing: Clinical and functional MRI observations. In Research issues. Symposium conducted at the annual meeting of the EMDR Europe Association, Brussels, Belgium.

Language: English

Format: Conference

Abstract:
It is proposed that enhanced mindfulness of emotions is a key factor in successful reprocessing of traumatic memories with EMDR. Clinical experience of utilising this focus will be presented. An attempt to study the hypothesis using functional magnetic resonance imaging will be described.

Keywords: MRI Research

Accuracy Verified: Yes

34. Thompson, M. M., Pasto, L., & McCreary, D. R. (2002, July). Empirical assessment of Lanius, et al.s’ “functional MRI of EMDR in peacekeepers,’ a review of the EMDR literature and an annotated bibiliography. Defence R&D Canada – Toronto, Technical Memorandum, DRDC Toronto.

Language: English

Format: Other

Abstract:
This report reviews a research proposal, the major objective of which is to assess the relation between PTSD (Post Traumatic Stress Disorder) and limbic, paralimbic, and prefrontal brain function as assessed with functional MRI (Magnetic Resonance Imaging), and to determine whether an Eye Movement Desensitization and Reprocessing (EMDR) intervention causes those structures to return to a normal mode of functioning. The proposed study secondarily explores the effectiveness of EMDR in reducing PTSD symptomatology. While the first and second objectives of the study may have scientific merit, the mandates of other funding agencies would appear to be more appropriate for investigations of basic neuroscience processes associated with brain functioning in PTSD (e.g., NSERC or CIHR). Importantly, a critical review of the EMDR research reveals that a great deal of controversy surrounds the effectiveness of this therapy. EMDR has not been shown to be more effective than presently validated PTSD exposure-based therapies, and the eye movement component of EMDR appears to provide no therapeutic benefit. Finally, there is a lack of clarity around specific items listed in the proposed budget. Given these concerns it is not recommended that this proposal be funded at this time.

Keywords: Bibliographies Canada Desensitizing' Magnetic Resonance Imaging Eye Movements Mental DIsorders MRI Medical Research Order Disorder Transofrmations Signs and Symptoms Stress (Physiology) Traumatic Shock

Accuracy Verified: Yes

35. deGraffenreid, D., & Page, R. (2009, April 18). The enhanced safe place: A practitioners guide to using multi sensory imaging to strengthen the safe place. Presentation at the Western Massachusetts EMDRIA Conference "EMDR and the Body," Amherst, MA.

Language: English

Format: Conference

Abstract:
Enhanced Safe Place (ESP) builds comfort and trust early in treatment. EP is especially effective in community MH settings. ESP contains preparatory information, multi sensory imaging, progressive relaxation and simple hypnotherapy techniques. Participants will practice the three stages (preparation, beginning, debriefing) and 10 specific techniques to help create highly effective body-oriented ESP experiences.

Keywords: Enhanced Safe Place

Accuracy Verified: Yes

36. deGraffenried, D. F. (2007, September). The enhanced safe place: A practitioner's guide to using multi sensory imaging to strengthen and augment the safe place. Presentation at the annual meeting of the EMDR International Association, Dallas, TX.

Language: English

Format: Conference

Abstract:
Multi sensory imaging techniques can dramatically strengthen the client’s Safe Place images resulting in a higher degree of client satisfaction, stronger development of the Safe Place and more effective affect management. This presentation will use a PowerPoint presentation to review 10 techniques, provide examples for their effective application and demonstrate with them via a client video tape.

Keywords: Enhanced Safe Place

Accuracy Verified: Yes

37. deGraffenried, D. (2008, September ). The enhanced safe place: A practitioners guide to using multi sensory imaging to strengthen and augment the safe place. Poster presented at the annual meeting of the EMDR International Association, Phoenix, AZ.

Language: English

Format: Conference

Keywords: Enhanced Safe Place Safe place

Accuracy Verified: Yes

38. Lamprecht, F., Kohnke, C., Lempa, W., Sack, M., Matzke, M., & Munte, T. F. (2004, June). Event-related potentials and EMDR treatment of post-traumatic stress disorder. Neuroscience Research, 49(2), 267-272. doi:10.1016/j.neures.2004.02.013.

Language: English

Format: Journal

Abstract:
10 patients suffering from PTSD following a severe traumatic event, were assessed with event-related brain potentials (ERPs) in a modified oddball paradigm containing auditory standard, target, and novel tones. ERPs were assessed before and after a treatment session using the eye movement desensitization and reprocessing method. Compared to a control group that underwent sham treatment, ERPs of the patients showed a reduction of the P3a component in the post-treatment recording, suggesting a reduced orienting to novel stimuli and reduced arousal level after the treatment. Moreover, psychometric assessment revealed a marked improvement of the PTSD symptoms after treatment. [Author Abstract]

Keywords: Brain Imaging Adults Cognitive Processes Empirical Study Germans Longitudinal Study Posttraumatic Stress Disorder Psychophysiology PTSD Quantitative Study Stressors Survivors Treatment Effectiveness

Accuracy Verified: Yes

39. Griffith, H. (2009, July). Evoking the embodied image with EMDR: Jung in the age of the brain. Presentation at the International Association for Jungian Studies Conference, Wales, Scotland.

Language: English

Format: Conference

Abstract:
A new paradigm for understanding psychopathology is emerging out of the convergence of research in formerly disparate domains such as neurobiology, attachment theory, and the effects of trauma. At the same time, unorthodox treatment modalities such as EMDR (Eye Movement Desensitization and Reprocessing) and the Energy therapies are beginning to gain favour in mainstream psychotherapy, not only because they seem to be supported by findings in fields such as neurobiology, but because they are so effective. As Jungians, I believe that our challenge is to revisit our work in the light of these latest scientific discoveries. In this paper, I first outline what brain imaging techniques are revealing about the importance of the dance between mother and infant in the actual hard-wiring of the babys developing brain. I then focus on trauma research, which shows how the release of stress induced hormones can result in the disorganization of the brain and the consequent shut down of integrative neuronal pathways. If we bring these two streams of research together we can see how early trauma within the parent infant bond, in which there is no adequate container to prevent the baby from falling into unbearable anxiety and terror, can initiate the hard-wiring of dysfunctional attitudes and behaviours that become reinforced throughout the childs development. I then briefly describe the EMDR protocol, which is proving to be a very effective technique in helping adult patients work through some of these dysfunctional patterns internalized in that very early parental dyad. This protocol uses a bilateral stimulation of the brain to engage a wider network of neuronal pathways to help process the painful psychological material, or complex, with which the patient is struggling. Facilitating a successful EMDR session is a little like witnessing a spontaneous active imagination as the patient weaves together the threads of a multitude of images, sensations, emotions, and cognitions into the fabric of a fuller, more nuanced, healing story of the self. The purpose of my paper is to demonstrate how these recent theoretical insights and treatment protocols can illuminate and enhance a Jungian approach to conducting psychotherapy. What I find remarkable is the compatibility between much of the contemporary research on the brain and many of Jungs ideas about the psyche. In this paper, however, I focus primarily on what we can learn about the complex. Drawing on numerous examples from case histories, I illustrate the effectiveness of the EMDR protocol in evoking the affect and embodied image at the core of the complex. I also demonstrate how the bilateral stimulation of the brain not only helps facilitate change but also, through the material which is engendered, gives us a window into how the complex was constructed in the first place.

Keywords: Brain Jung

Accuracy Verified: No

40. Zoler, M. (1998, August). Eye movement desensitization: Brain imaging shows benefit of PTSD therapy. Clinical Psychiatry News, 26(8), 14.

Language: English

Format: Newspaper

Abstract:
The efficacy of a controversial treatment for posttraumatic stress disorder has been boosted for new evidence from brain imaging studies.

Keywords: Brain Imaging Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

41. Fay, D., Corrigan, F. Fisher, J., Galloway, J., & Mcafee, F. (2010, April). An fMRI study of the integration of “Becoming safely embodied” and EMDR techniques for the de-activation of fear motor neurocircuitry. Symposium presented at the 2nd Bi-Annual International European Society for Trauma and Dissociation, Belfast, Northern Ireland.

Language: English

Format: Conference

Abstract:
An fMRI Study of the Integration of “Becoming Safely Embodied” and EMDR Techniques for the De-Activation of Fear Motor Neurocircuitry Frank Corrigan, Consulting Psychiatist, Argyll & Bute Hospital, Lochgilphead, Argyll This panel discussion explores brain imaging results using BSE skills activating left anterior insula intensified with alternating bilateral stimulation (ABS) from Eye Movement Desensitisation and Reprocessing (Shapiro 1992). It suggests positive feelings associated with brain activations deactivate areas involved in motor responses to threat.

Keywords: Fear Motor Neurocircuitry fMRI Study

Accuracy Verified: Yes

42. Ohtani, T., & Matsuo, K. (2006). Functional abnormality of the prefrontal cortex in posttraumatic stress disorder: Psychophysiology and treatment studies assessed by near-infrared spectroscopy. In N. Kato; M. Kawata, & Pitman, R. K (Eds.), PTSD: Brain mechanisms and clinical implications (pp. 235-245). Tokyo: Springer-Verlag.

Language: English

Format: Book Section

Abstract:
A growing number of functional neuroimaging studies on PTSD have described the abnormal response of amygdala and prefrontal cortex to traumatic stimuli. Abnormal activation of some parts of the prefrontal cortex might possibly be involved in the pathophysiology of PTSD. [Adapted from Text, pp. 235-236]TOPICS TREATED: Near-infrared spectroscopy (NIRS); NIRS studies in PTSD; Neuroimaging studies of treatment in PTSD (Selective-serotonin reuptake inhibitor [SSRI] and Eye movement desensitization and reprocessing [EMDR].([Adapted from Text, pp. 235-236] [Pilots]

Keywords: Brain Imaging Neuroanatomy Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

43. Pagani, M. (2013, June). Functional and structural neuroimaging and EEG monitoring related to EMDR and CBT treatments for PTSD. Presentation at the 13th annual conference for the European Society for Traumatic Stress Studies (ESTSS), Bologna, Italy.

Language: English

Format: Conference

Abstract:
In the recent past several neuroimaging studies aimed at evaluating the neural correlates of PTSD-related psychotherapies revealing their neurobiological effects on brain function. Functional studies by single photon emission computed tomography (SPECT) and electroencephalography (EEG) detected changes in cerebral blood flow and neuronal activation patterns, identifying the brain areas implicated in the various components of emotional processing and/or affected by the disorder. Investigations by magnetic resonance imaging (MRI) have also revealed PTSD-related structural changes. The first part of the workshop will review the neuroimaging methodologies and findings in PTSD treatment-related research with an extensive review of previous literature on the neurobiological effects of the various psychotherapies. The second part will deal with the description and implementation in research and clinic of neuropsychological testing with brief comments and discussion about their use in recent studies published by our group. In the third part the EEG monitoring of a complete set of Eye Movement Desensitization and Reprocessing therapies in 30 patients suffering of major trauma as compared to 20 healthy controls will be presented. These findings will also be compared to the neurobiological effects of trauma-focussed Cognitive Behavioural Therapy in a second group of psychologically traumatized clients. The results are the first report ever on the neurobiological changes occurring before, during and after PTSD-related psychotherapies shedding light on the neuronal processes underlying their clinical efficacy. The description and the discussion about the contents of the workshop will provide the audience (1) the necessary information to understand the methodological principles behind neuroimaging techniques (SPECT, EEG and MRI) and their possible applications in research and clinic; (2) the up-dated critical knowledge of the published papers in the field of PTSD-related psychotherapies functional and anatomical studies; (3) the basic research principles and examples to be motivated to start, take part and/or collaborate to functional studies in order to better understand the neural basis of psychotherapeutic techniques. The presented material will represent the state-of-the-art of the current neuroscience PTSD-related research and of the neuroimaging methodologies available at the moment.

Accuracy Verified: Yes

44. Langwig, K. E. (2008, December). A functional magnetic resonance imaging study of the effects of eye movement desensitization and reprocessing therapy on post-traumatic stress disorder car accident patients: A pilot study. Union College, Schenectady, N.Y.

Language: English

Format: Dissertation/Thesis

Abstract:
Eye movement desensitization and reprocessing (EMDR) therapy is a novel therapy that has been effective in treating post-traumatic stress disorder (PTSD). Few studies have explored the neurological underpinnings of EMDR effectiveness. Utilizing a symptom provocation study design, this study assessed non-PTSD car accident patients. These pilot participants were scanned for comparison to PTSD patients and to explore the task design effectiveness for the future study of PTSD patients. One pilot participant exhibited activation in the left precuneus, and left medial temporal gyrus, and also in the left medial frontal gyrus. In PTSD patients the medial prefrontal cortex is often hypoactive, and inversely correlated with a hyperactive amygdala. The robust activation of medial frontal gyrus in the pilot subject with a corresponding inactivation of the amygdala indicates the participant's normal processing of the car accident trauma tic memories, and that task design and study parameters are being effectively implemented.

Keywords: Automobile Accidents Car Accidents fMRI Pilot Study Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

45. Staff. (2009). Getting it right. KCAL, Los Angeles, CA.

Language: English

Format: Video

Abstract:
Getting it Right TV station KCAL in Los Angeles is a welcome exception to the common practice of reporting combat PTSD as untreatable. A video clip on their website reports how a Desert Storm vet rushed to assist victims of a recent automobile accident in Santa Monica and experienced a combat-based flashback. The video recounts his subsequent successful EMDR therapy with HAP supporter Sarah Gilman after diagnosis at Dr. Daniel Amen’s imaging research clinic.

Keywords: Practice Theory

Accuracy Verified: Yes

46. Pagani, M., Nardo, D., Höberg, G., & Larson, S. (2009, November). Gray matter changes in limbic cortex in PTSD are associated with trauma load and EMDR outcome. Presentation at the 25th annual meeting of the International Society for Traumatic Stress Studies, Atlanta, GA.

Language: English

Format: Conference

Abstract:
Psychophysiological Research
There is converging evidence of gray matter (GM) structural alterations in different limbic structures in Post-Traumatic Stress Disorder (PTSD) patients. The aim of this study was to evaluate GM reduction in PTSD in relation to trauma load, and to assess the volumetric differences between responders (R) and non-responders (NR) to EMDR therapy. Magnetic Resonance Imaging scans of 21 subjects exposed to occupational trauma, who developed PTSD (S), and of 22 who did not (NS), were compared by means of an optimized Voxel-Based Morphometry (VBM) analysis as implemented in SPM. Within S, further comparisons were made between 10 R and 5 NR. A regression analysis between GM density and the Traumatic Antecedents Questionnaire (TAQ) was also performed on all 43 subjects. Results showed a highly significant GM volume reduction in S as compared to NS, bilaterally in posterior cingulate and in the left hemisphere in precuneus, lingual and parahippocampal gyri. Moreover, NR showed a highly significant GM volume reduction as compared to R in bilateral posterior cingulate, as well as insula, parahippocampal gyrus and amygdala in the right hemisphere. Regression analysis showed that GM volume reductions positively correlated with trauma load in bilateral anterior and posterior cingulate and right parahippocampal gyrus. In conclusion, GM volume reductions in posterior cingulate and parahippocampal cortex were associated with PTSD diagnosis, trauma load, and EMDR treatment outcome.

Keywords: Limbic Cortex Posttraumatic Stress Disorder PTSD Outcome Trauma Load

Accuracy Verified: Yes

47. Nardo, D., Hogberg, G., Looi, J. C., Larsson, S., Hallstrom, T., & Pagani, M. (2010, May). Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients. Journal of Psychiatric Research, 44(7), 477-485. doi:10.1016/j.jpsychires.2009.10.014.

Language: English

Format: Journal

Abstract:
There is converging evidence of gray matter (GM) structural alterations in different limbic structures in Post-Traumatic Stress Disorder (PTSD) patients. The aim of this study was to evaluate GM density in PTSD in relation to trauma load, and to assess the GM differences between responders (R) and non-responders (NR) to EMDR therapy. Magnetic Resonance Imaging (MRI) scans of 21 subjects exposed to occupational trauma, who developed PTSD (S), and of 22 who did not (NS), were compared by means of an optimized Voxel-Based Morphometry (VBM) analysis as implemented in SPM. Within S, further comparisons were made between 10 R and 5 NR. A regression analysis between GM density and the Traumatic Antecedents Questionnaire (TAQ) was also performed on all 43 subjects. Results showed a significantly lower GM density in S as compared to NS in the left posterior cingulate and the left posterior parahippocampal gyrus. Moreover, NR showed a significantly lower GM density as compared to R in bilateral posterior cingulate, as well as anterior insula, anterior parahippocampal gyrus and amygdala in the right hemisphere. Regression analysis showed that GM density negatively correlated with trauma load in bilateral posterior cingulate, left anterior insula, and right anterior parahippocampal gyrus. In conclusion, a GM lower density in limbic and paralimbic cortices were found to be associated with PTSD diagnosis, trauma load, and EMDR treatment outcome, suggesting a view of PTSD characterized by memory and dissociative disturbances.[Pubmed]

Keywords: Limbic Cortex Posterior Cingulate Posttraumatic Stress PTSD

Accuracy Verified: Yes

48. Pagani, M. (2010, June). Gray matter density is associated with EMDR outcome in PTSD patients. In Research. Symposium conducted at the annual meeting of the EMDR Europe Association, Hamburg, Germany.

Language: English

Format: Conference

Abstract:
There is converging evidence of gray matter (GM) structural alterations in different limbic structures in Post-Traumatic Stress Disorder patients. Eye Movement Desensitization Reprocessing (EMDR) is currently used to treat PTSD but its neurobiological implications are still unknown. The aim of this study was to evaluate GM density in PTSD relation to trauma load, and to assess the GM differences between responders (R) and non-responders (NR) to EMDR therapy. Structured clinical interviews for DSM-IV Axis I Disorders were carried out before and after EMDR treatment. Those who no longer fulfilled the DSM-IV criteria for PTSD were classified as R and those who still met the diagnostic criteria of PTSD after treatment were classified as NR. Two scales 0f self-related Trauma Antecedent Questionnaire (‘trauma and neglect’ TAQ-, and ‘resilience factors’ TAQ+), were administered to assess lifelong trauma load and resilience. Magnetic Resonance Imaging (MRI) scans 10 R and of 5 NR were compared before therapy by means of an optimized Voxel-Based Morphometry (VBM) analysis as implemented in SPM. For group analysis, a threshold of p<0.05 corrected for multiple comparisons at cluster level and an uncorrected threshold of p <0.001 at voxel-level were used. NR subjects showed no significant differences nor in TAQ- scores neither in TAQ+ as compared to R(t=0.140, p+0.891). The contract R>NR exhibited a significant GM lower density in NR as compared to R in three different cluster: the first bilaterally located over posterior cingulate (Brodmann Areas, Bas 23 and 31); the second centered over the left precentral (BA 4), middle and medial frontal gyri (BA 6); the third including anterior insula (BA 13), and the complex anterior parahippocampal gyrus/amygdala, over the right hemisphere. To our knowledge, this is the first study investigating GM alterations with a VBM approach in a sample of PTSD patients respond and non responding to EMDR therapy. Posterior cingulate, parahippocampal and insular lower GM concentrations have been found to relate to responsiveness to EMDR therapy suggesting a high vulnerability of these structures to the effects of stress and trauma. These regions are well known to be implicated in processes such as: integration, encoding and retrieval of autobiographical and episodic memories; emotional processing, interoceptive awareness and sefl-referential conscious experience. Thus, our study supports lower GM densities in limbic and paralimbic cortices as a potential structural basis for memory and dissociative dysfunction in PTSD. Using such methodological approach can contribute to better understand the neurostructural basis for traumatic responses and their treatment. The goals for the audience are: 1. To understand the methodological research principles; 2. To be updated on neurobiological research in EMDR; 3. to be informed on the neural basis of EMDR.

Keywords: Gray Matter Posttraumatic Stress Disorder PTSD Research Symposium

Accuracy Verified: Yes

49. Lansing, K., Amen, D. G., Hanks, C., & Rudy, L. (2005, Fall). High-resolution brain SPECT imaging and eye movement desensitization and reprocessing in police officers with PTSD. Journal of Neuropsychiatry and Clinical Neuroscience, 17(4), 526-532. doi:10.1176/appi.neuropsych.17.4.526.

Language: English

Format: Journal

Abstract:
Eye movement desensitization and reprocessing (EMDR) has been shown to be an effective treatment for PTSD. In this study, the authors evaluated the effectiveness and physiological effects of EMDR in police officers involved with on-duty shootings and who had PTSD. 6 police officers involved with on-duty shootings and subsequent delayed-onset PTSD were evaluated with standard measures, the Posttraumatic Stress Diagnostic Scale (PDS), and high-resolution brain single photon emission computed tomography (SPECT) imaging before and after treatment. All police officers showed clinical improvement and marked reductions in the PDS score. In addition, there were decreases in the left and right occipital lobe, left parietal lobe, and right precentral frontal lobe as well as significant increased perfusion in the left inferior frontal gyrus. In our study EMDR was an effective treatment for PTSD in this police officer group, showing both clinical and brain imaging changes. [Author Abstract]

Keywords: Empirical Study Off-Duty Shootings Police Officers Posttraumatic Stress Disorder PTSD Quantitative Study SPECT

Accuracy Verified: Yes

50. Lansing, K. (2004, November). Images of healing: SPECT images of PTSD and recovery in police officers. Preconference presentation at the 20th annual meeting of the International Society of Traumatic Stress Studies, New Orleans, LA.

Language: English

Format: Conference

Abstract:
The effects of “lethal contact” (i.e., close range firefights) in both the military and law enforcement populations can render long-standing psychological impairment. In this study we evaluated the effectiveness and physiological effects of EMDR in police officers involved with on-duty shootings who had delayed PTSD. Method: Six police officers involved with on-duty shootings and subsequent delayed-onset PTSD were evaluated with standard measures, the Posttraumatic Stress Diagnostic Scale and high-resolution brain SPECT imaging, before and after treatment. Results: All police officers showed clinical improvement and marked reductions in the PDS (mean reduction from scores of 43.2 pre EMDR to 5.2 post EMDR). In addition, there were decreases in the left and right occipital lobe, left parietal lobe and right precentral frontal lobe, as well as significant increased perfusion (>0.001) in the left inferior frontal gyrus. Conclusions: In our study EMDR was an effective treatment for PTSD in this police officer group, showing both clinical and brain imaging changes. This multimedia presentation integrates selected case reviews including the dispatch recordings of the officer’s actual shooting incident/s, follow-up “check-in” messages documenting the officer’s reactions upon return to duty as well as pre- and post-treatment brain images. Brief selections of video also are used to further illustrate key principals. Clinical methodologies that were used with this group of subjects also will be discussed. Participant Alert: EMDR is a stepwise protocol designed to facilitate the reexperiencing of “trauma based” memories in order to assist the client in reformatting them into a non-disturbing / more “normalized” memory. During this protocol highly charged/upsetting images, feelings or experiences can arise for the client.

Keywords: Police Officers SPECT

Accuracy Verified: Yes

51. Bender, S. S., Lange, G., Steffener, J., Bergmann, U., Grand, D., Liu, W-C., & Bly, F. M. (2002, June). Imaging violence: Posttraumatic stress disorder, eye movement desensitization and reprocessing, and functional resonance imaging. Poster presented at the annual meeting of the EMDR International Association, San Diego, CA.

Language: English

Format: Conference

Keywords: FRI Functional Resonance Imaging Imaging Violence Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

52. Flumeri, F., Salmaso, D., & Pagani, M. (2008, 26-28 Settembre). Impatto dell'EMDR sulle fuzioni e sulla neurobiologia cerebrali [Impact on EMDR and neurobiological brain functions]. In T. Farma (Chair), Simposio, Il modello psicotraumatologico: Un ponte tra indicatori neurobiologici e Psicoterapia. VII Congresso SPR Italia, Modena.

Language: Italian

Format: Conference

Abstract:
Introduzione:negli ultimi anni il numero di studi condotti nell’ambito dei disturbi causati da eventi traumatici ha subito una forte accelerazione rilevando l’esistenza di alterazioni fisiologiche e morfologiche in specifiche aree cerebrali associate sia alla risposta emotiva al trauma che alla insorgenza dei sintomi della sindrome da stress post-traumatico (PTSD). L’impiego delle tecniche di neuroimmagine ha consentito di fare luce sui correlati neurali della psicoterapia, rivelando i suoi effetti neurobiologici sulla funzione cerebrale. Nell’ambito dei diversi approcci psicoterapeutici, l’EMDR (Eye Movement Desensitization and Reprocessing therapy) è emerso come promettente risorsa per il trattamento del trauma e di altri disturbi d’ansia, sebbene ancora non sia stata completamente chiarita la sua modalità di azione sui circuiti neurali. Molte ricerche sono state effettuate per valutare l’efficacia dell’EMDR, ma solo un numero esiguo di esse ha indagato il substrato neurobiologico di questa psicoterapia. Le metodiche di neuroimmagini utilizzate finora per studi sull’EMDR sono la Single Photon Emission Computed Tomography (SPECT) e la Magnetic Resonance Imaging (MRI). La prima raccoglie dati sull’attivita’ cellulare cerebrale mentre la seconda riporta dati anatomici strutturali. Gli studi funzionali condotti con SPECT consentono di identificare le variazioni del metabolismo e del flusso ematico cerebrale, suggerendo un ruolo specifico per ciascuna area cerebrale coinvolta nel complesso meccanismo che sottende il processamento delle emozioni; la MRI consente invece di rilevare la presenza di variazioni morfologiche e volumetriche di specifiche strutture cerebrali. Negli ultimi anni, studi SPECT e MRI, volti ad esaminare gli effetti dell’EMDR sulla fisiopatologia cerebrale in pazienti affetti da disturbi d’ansia, hanno riscontrato sostanziali variazioni del flusso ematico ed alterazioni strutturali di alcune regioni cerebrali in seguito a terapia. L’efficacia dell’EMDR nel trattamento del PTSD è stata confermata da uno studio SPECT su sei soggetti ( Lansing et al.) (1) che ha evidenziato dopo terapia una diminuzione del flusso ematico nel lobo occipitale bilateralmente e nel lobo parietale sinistro e un aumento di flusso nel giro frontale inferiore sinistro. Sempre utilizzando la SPECT Oh e Choi (2) hanno riportato una significativa modificazione del flusso cerebrale in seguito ad EMDR, prevalentemente riscontrabile nell’area limbica e nella corteccia prefrontale. Un recente studio con utilizzo di MRI (3) ha inoltre messo in evidenza un aumento di volume dell’ippocampo in seguito a trattamento con EMDR, aumento invece non riportato in un lavoro di Lindauer et al. su 9 soggetti con PTSD, nonostante il successo clinico della psicoterapia eclettica eseguita (4). Obiettivi: il nostro gruppo ha studiato gli effetti a breve e lungo termine dell’EMDR (5, 6) dimostrando la sua efficacia nel trattamento di soggetti traumatizzati sul lavoro, e una stabilità del miglioramento clinico ottenuto in risposta alla terapia, ancora presente a distanza di tre anni. Nell’ambito dello stesso progetto sono state anche studiate le variazioni del flusso ematico cerebrale e della volumetria di alcune strutture cerebrali in relazione alla terapia con EMDR. Un primo studio SPECT ha analizzato la variazione della distribuzione di flusso in 11 soggetti guariti clinicamente da PTSD in seguito a EMDR messi a confronto con 5 soggetti nei quali la terapia non ha avuto effetto (7). Risultati: è stato evidenziato nei soggetti con remissione sintomatologica significative differenze di flusso in 4 aree corticali, alla disfunzione delle quali sono ascrivibili alcuni sintomi presenti in corso di PTSD. Diminuzioni di flusso post-terapia sono state registrate nell’ippocampo, nella corteccia parieto-occipitale e nella corteccia visiva primaria. L’ippocampo e’ sede della memoria a breve termine; la corteccia parieto-occipitale processa il riconoscimento di volti, dei corpi e delle parole; la corteccia visiva primaria custodisce la memoria visiva degli eventi. La mancata inibizione e/o l’iperattivita’ di queste regioni nel PTSD sono responsabili della rivisitazione patologica dell’evento traumatico e della presenza di flashback ed immagini allucinatorie. Inoltre la corteccia frontale dorsolaterale ha dimostrato un aumento di flusso nei soggetti che hanno risposto positivamente alla terapia. Questa regione chiave oltre ad essere deputata ad inibire la risposta patologica a stimoli che ricordano l’evento traumatico e’ essenziale per i processi di attenzione e di autostima, diminuiti in corso di PTSD e recuperati in seguito alla remissione della malattia. In ulteriori studi che combinano indagini funzionali e strutturali utilizzando SPECT e MRI abbiamo messo in evidenza il valore predittivo delle dimensioni dell’ippocampo riguardo all’efficacia della terapia con EMDR (Pagani et al. sottomesso). Conclusioni: gli effetti della terapia con EMDR sono risultati, unitamente ad un consistente miglioramento della sintomatologia e ad una riduzione della iperreattività a stimoli di carattere emotivo, in una normalizzazione funzionale di alcune aree specifiche e in un aumento del volume ippocampale probabilmente ascrivibile a neo-neurogenesi. Questi risultati sono in linea con la pregressa letteratura e con le attuali conoscenze sul PTSD e suggeriscono basi neurobiologiche dell’effetto terapeutico dell’EMDR confermandone l’impatto funzionale su strutture cerebrali coinvolte in patologie ansiogene. Bibliografia: 1. Lansing et al. (2005). J Neuropsych Clin Neurosci;17(4):526-532. 2. Ho DH and Choi J. (2007). J EMDR Pract Res;1(1):24-30. 3. Bossini et al. (2007). J Neuropsych Clin Neurosci; 19(4):475-476. 4. Lindauer et al. (2005). Psychol Med ; 35 :1-11. 5. Hogberg et al. (2007). Nord J Psych; 61(1):54-61. 6. Hogberg et al. (2008). Psych Res; doi:10.1016/j.psychres.2007.10.019. 7. Pagani et al. (2007). Nuc Med Comm; 28(10):757-65. [Pagani abstract]

Introduction In recent years the number of studies in disorders caused by traumatic events has been greatly accelerated by detecting the existence of morphological and physiological changes in specific brain areas associated with both the emotional response to trauma to the onset of symptoms Post-traumatic stress syndrome (PTSD). The use of neuroimaging techniques has allowed to shed light on the neural correlates of psychotherapy, revealing the neurobiological effects on brain function. Under the different psychotherapeutic approaches, EMDR (eye movement desensitization and reprocessing therapy) has emerged as a promising resource for the treatment of trauma and other anxiety disorders, although still not been fully elucidated its mode of action on neural circuits. Many studies have been carried out to assess the effectiveness EMDR, but only a small number of them have investigated the neurobiological substrate of this psychotherapy. The methods used so far for neuroimaging studies on EMDR are Single Photon Emission Computed Tomography (SPECT) and Magnetic Resonance Imaging (MRI). The first collects data on 'brain cells while the second contains structural anatomical data. The functional studies performed with SPECT to identify changes in metabolism and cerebral blood flow, suggesting a specific role for each brain area involved in the complex mechanism underlying the processing of emotions, instead of MRI allows detection of morphological changes and volume of specific brain structures. In recent years, MRI and SPECT studies, aimed to examine the effects of EMDR on brain pathophysiology in patients with anxiety disorders, have found substantial variations in blood flow and structural alterations of some brain regions after treatment. The effectiveness of EMDR in the treatment of PTSD was confirmed by a SPECT study in six subjects (Lansing et al.) (1) showed that after treatment reduced blood flow in the occipital lobe bilaterally and in left parietal lobe and a increase of flow in left inferior frontal gyrus. Always using SPECT Oh and Choi (2) reported a significant change of cerebral blood flow after EMDR, mainly found in limbic and prefrontal cortex. A recent study using MRI (3) has also highlighted an increase in volume of the hippocampus after treatment with EMDR, but no increase in reported work of Lindauer et al. on 9 subjects with PTSD, despite the clinical success of eclectic psychotherapy performed (4). Objectives: Our group has studied the effects of short and long term EMDR (5, 6) demonstrating its effectiveness in treating traumatized individuals at work, and stability of clinical improvement obtained in response to therapy, yet this distance three years. Within the same project were also studied changes in cerebral blood flow and volume of certain brain structures in relation to treatment with EMDR. A first SPECT study analyzed the change in flow distribution in 11 subjects clinically recovered from PTSD after EMDR compared with 5 subjects in whom treatment had no effect (7). Results: It was shown in patients with symptomatic remission, significant differences in flow in 4 cortical areas, which are attributable to dysfunction of some symptoms of PTSD being present. Flow decreases post-treatment were recorded in the hippocampus, cortex parietal-occipital and primary visual cortex. The hippocampus and 'seat of short-term memory, the parietal-occipital cortex processes the recognition of faces, bodies and words, the primary visual cortex preserves the visual memory of events. The lack of inhibition and / or 'hyperactivity' of PTSD in these regions are responsible for the pathological review of the traumatic event and the presence of flashbacks and hallucinatory images. Moreover, the dorsolateral frontal cortex showed an increase in flow in subjects who responded positively to therapy. This key region in addition to being appointed to inhibit the pathological response to stimuli that recall the traumatic event and 'essential for the processes of attention and self-esteem, decreased in the course of PTSD and recovered following the remission of the disease. In further studies that combine functional and structural investigations using SPECT and MRI have shown the predictive value of the size of the hippocampus on the effectiveness of EMDR therapy (Pagani et al. Submitted). Conclusion: the effects of EMDR therapy were coupled with a significant improvement in symptoms and a reduction of hyperreactivity to stimuli, emotional, functional in a normalization of some specific areas and an increase in hippocampal volume probably due to neo- neurogenesis. These results are consistent with previous literature and with current knowledge about PTSD and suggest a neurobiological basis of therapeutic EMDR confirming the functional impact on brain structures involved in anxiety-disorders. Bibliography: 1. Lansing et al. (2005). J Neuropsych Clin Neurosci, 17 (4) :526-532. 2. I DH and J. Choi (2007). J EMDR pract Res, 1 (1) :24-30. 3. Bossini et al. (2007). J Neuropsych Clin Neurosci, 19 (4) :475-476. 4. Lindauer et al. (2005). Psychol Med, 35 :1-11. 5. Högberg et al. (2007). Nord J Psych, 61 (1) :54-61. 6. Högberg et al. (2008). Psych Res, doi: 10.1016/j.psychres.2007.10.019. 7. Pagani et al. (2007). NUC Med Comm, 28 (10) :757-65. [Pagani abstract]

Keywords: Brain Functions Neurobiology

Accuracy Verified: Yes

53. Pagani, M. (2010, June). Introduction to neuroimaging in EMDR research. Presentation at the annual meeting of the EMDR Europe Association, Hamburg, Germany.

Language: English

Format: Conference

Abstract:
In the recent years the number of neuroimaging studies evaluating neural correlates of psychotherapy has steadily increased revealing its clear neurobiological effects on brain function across a wide range of psychiatric disorders. Functional studies by single photon emission computed tomography (SPECT) and positron emission tomography (PET) detect changes in cerebral blood flow and metabolism patterns, identifying the brain areas processing the various components of emotional processing and/or affected by the disorders. investigations by magnetic resonance imaging (MRI) have also revealed psychiatry disease-related structural changes. The first part of the workshop (20 minutes) will describe the neuroimaging methodologies implemented in EMDR research and their possible clinical implementations will be discussed. In the second part (10 minutes) neuroimaging studies on the neurobiological effect of EMDR will be reviewed (1-5). The third part of the workshop (30 minutes) will deal with the last findings in EMDR research and will focus on a recent studies published by our group on the Journal of Psychiatry Research about the predictive value of MRI on the outcome of EMDR therapy (6).Moreover a collaborator of our group will describe and present the preliminary findings of an ongoing experiment aiming to identify the neurophysiological mechanisms active during EMDR therapy. The description and the discussion about the contents of the workshop will provide the audience 1 the necessary information to understand the methodological principles behind the neuroimaging techniques (PET and SPECT) and their possible applications in research and clinic; 2, the critical knowledge of the limited number of published papers in the field of EMDR-related functional and anatomical studies (1-6); 3. the basic research principles and examples to be motivated to begin, take part and/or collaborate to EMDR research in order to shed light on the neural basis of this fascinating psychotherapeutic technique. The presented material will represent the state-of-the-art of the current neuroscience EMDR-related research and of the neuroimaging methodologies available at the moment. in case more contributions will be included in this workshop the proposed presentation time schedule might change. References: Lansing et al. (2005). J Neuropsych Clin Neurosci; l7(4):526-532. Propper et al. (2007). J Nerv Met Dis; 195:785-788. Ho DH and Choi J. (2007). J EMDR Pract Res; l(l):24-30. Pagani et al. (2007). Nuc Med Comm: 28(10):757-65. Bossini et al (2007). J Neuropsych Clin Neurosci; 19(4):475-476. Nardo et al. (2010). J Psychiatry Res; D0110.1016/jjpsychires.2009.10.014

Keywords: Neuroimaging Research

Accuracy Verified: Yes

54. Bossini, L., Tavanti, M., Calossi, S., Marino, G., Pieraccini, F., Vatti, G., & Castrogiovanni, P. (2008, Novembre). Le modificazioni del volume hippocampale dopo una terapia con EMDR nel PTSD [EMDR treatment for PTSD: effect on hippocampal volume]. Plenaria presentato le applicazioni cliniche di EMDR Congresso Nazionale, Milano, Italia.

Language: Italian

Format: Conference

Abstract:
Molti studi di Risonanza Magnetica (RM) hanno mostrato che in pazienti con Disturbo Post-Traumatico da Stress (DPTS) è presente un volume ippocampale più piccolo se confrontato con i controlli sani. Allo stesso tempo altre indagini hanno mostrato che i farmaci psichiatrici bloccano gli effetti dello stress nell’ippocampo e promuovano la neurogenesi a livello ippocampale. Comunque il solo studio che ha investigato gli effetti di un tipo di psicoterapia non ha evidenziato modificazioni volumetriche significative (1). Scopo dello Studio: Scopo dello studio è indagare gli effetti del trattamento con EMDR (Eye Movement Desensitization and Reprocessing) sul volume ippocampale e sui sintomi clinici di un gruppo di pazienti con DPTS. Metodologia: Abbiamo paragonato gli ippocampi di 9 pazienti con DPTS cronico e mai sottoposti ad alcun tipo di terapia (farmacologica e/o psicoterapica) a 9 soggetti sani accoppiati per sesso, età e scolarità. La diagnosi e la severità del DPTS è stata misurata tramite la Clinician-Administered PTSD Scale (CAPS) (Fase 1). Successivamente tutti i soggetti con DPTS sono stati sottoposti a 12 sedute settimanali di EMDR della durata di 90 minuti ciascuna e nuovamente sottoposti a valutazione clinica e RM (Fase 2). Risultati: Fase 1 - E’ stata scelta una p inferiore di .05 per indicare la significatività statistica. L’analisi della covarianza (ANCOVA) con l’emisfero (ippocampo sinistro vs. ippocampo destro) come fattore ripetuto, il volume totale cerebrale come covariata ha mostrato che i soggetti con DPTS hanno il volume ippocampale più piccolo rispetto ai controlli (F=12.53, d.f=1,15, p=.003). La media del punteggio della CAPS nei soggetti con DPTS era 55.78 ± 21.74. Fase 2 - Il trattamento con EMDR è associate ad un incremento del volume ippocampale sia a destra (5.9 %) (t=-3.34, df=8, p=.010) sia a sinistra (6.1 %) (t=-3.27, df=8, p=.011). I risultati indicano anche che il trattamento con EMDR produce un significativo decremento del punteggio totale della CAPS (da 55.78±21.74 a 19.33±15.49; t=4.78, df=8, p=.001 Conclusioni: La prima parte dello studio conferma i dati che mostrano che i soggetti con DPTS hanno un ippocampo più piccolo dei controlli sani La seconda parte suggerisce che il trattamento con EMDR può essere associato ad un miglioramento sintomatologico e ad un incremento del volume degli ippocampi. Questi risultati suggeriscono l’opportunità di continuare ad indagare gli effetti biologici delle psicoterapie.

Many studies of Magnetic Resonance Imaging (MRI) showed that in patients with Post-Traumatic Stress Disorder (PTSD) is a smaller hippocampal volume compared with healthy controls. At the same time other studies have shown that psychiatric drugs block the effects of stress and promote hippocampus neurogenesis in the hippocampus. However, the only study that investigated the effects of a type of psychotherapy showed no significant volume changes (1). Objective: The purpose of this study is to investigate the effects of treatment with EMDR (eye movement desensitization and reprocessing) on hippocampal volume and clinical symptoms of a group of patients with PTSD. Methods: We compared the hippocampi of nine patients with chronic PTSD and never subjected to any kind of treatment (pharmacological and / or psychotherapy) in 9 healthy subjects matched for sex, age and education. The diagnosis and severity of PTSD was measured by the Clinician-Administered PTSD Scale (CAPS) (Phase 1). Then all subjects with PTSD were subjected to 12 weekly sessions of EMDR lasting 90 minutes each and again subjected to clinical evaluation and MRI (Phase 2). Results: Step 1 - E 'was chosen p less than .05 to indicate statistical significance. The analysis of covariance (ANCOVA) with hemisphere (left vs. hippocampus. Right hippocampus) as repeated factor, the total brain volume as covariate showed that individuals with PTSD have smaller hippocampal volume than controls (F = 12:53 , df = 1.15, p =. 003). The average score of the CAPS in subjects with PTSD was 55.78 ± 21.74. Step 2 - Treatment with EMDR is associated with an increase in both right hippocampal volume (5.9%) (t =- 3:34, df = 8, p =. 010) and left (6.1%) (t =- 3.27, df = 8, p =. 011). The results also indicate that treatment with EMDR produces a significant decrease in the CAPS total score (from 21.74 to 55.78 ± 19:33 15:49 ± t = 4.78, df = 8, p =. 001 Conclusion: The first part of the study confirms the data showing that individuals with PTSD have a smaller hippocampus of healthy controls The second part suggests that treatment with EMDR may be associated with symptomatic improvement and an increase in the volume of the hippocampus. These results suggest the desirability of continuing to investigate the biological effects of psychotherapy.

Keywords: Hippocampal Volume Plenary Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

55. Stairs, F. (2001, May 14). Letters: Save the baby. Detroit, MI: The Detroit News, No Dot, Letters, 08A.

Language: English

Format: Newspaper

Abstract:
One appears to be Eye Movement Desensitization and Reprocessing (EMDR), an extensively researched therapeutic technique with scientifically proven powerful effects in relieving traumatic memory. There is brain imaging research that identifies the specific brain activities and changes created by EMDR. And no scientific body has ever found the slightest amount of hypnotic activity to be involved with EMDR therapy as provided by EMDR Institute-trained personnel.

Keywords: Detroit Letter

Accuracy Verified: Yes

56. Janse, J., & Doornkate, L. (2012, June). Listening with your eyes: Exploring visual aspects of the EMDR-process [Escuchar con los ojos: la exploración de los aspectos visuales del proceso de EMDR]. Presentation at the annual meeting of the EMDR Europe Association, Madrid, Spain.

Language: English

Format: Conference

Abstract:
In our therapeutic EMDR work with deaf and hard of hearing clients, we are forced to strongly focus on the visual world. But focus on visual aspects is not only necessary with this client group! When working with pre-‐verbal trauma, with children or adults who are (not yet) fluent in their native speech or when we use EMDR with clients that use a second language, we will have to use alternatives to spoken languages. When used correctly, visual input can enrich and enable the EMDR process greatly. In this presentation we invite visitors to explore the visual aspects and possibilities of the EMDR process with us. Visitors will feel more adequate in using mimic, visual and imaging techniques with their clients. Video material will enrich our presentation. We will present in English and Dutch sign language. Our interpreter will translate the Dutch sign language in spoken English.

En nuestro trabajo terapéutico con EMDR con clientes sordos o con hipoacusia, nos vemos obligados a centrarnos mucho en el mundo visual. Sin embargo, ¡el énfasis en los aspectos visuales no solo es necesario con este grupo de pacientes! Cuando trabajamos con trauma acaecido durante el período pre-‐verbal, con niños o con adultos que (aún) no dominan su lengua materna o cuando usamos EMDR con clientes que hablan un segundo idioma, tendremos que hacer uso de alternativas a las lenguas habladas. Cuando se emplea correctamente, el input visual puede enriquecer y capacitar el proceso con EMDR mucho. En esta presentación, invitamos a los visitantes a acompañarnos en nuestra exploración de los aspectos visuales y de las posibilidades del proceso con EMDR. Los visitantes se sentirán más apropiados con la utilización de la mímica y las técnicas visuales y de imagen con sus clientes. Los vídeos servirán para enriquecer nuestras presentaciones. Presentaremos en inglés y en el lenguaje de signos del neerlandés. Nuestra intérprete traducirá de lenguaje de signos neerlandés en inglés hablado.

Keywords: Visual Aspects of EMDR Process

Accuracy Verified: Yes

57. Tokunaga, H., Ikejiri, Y., Kazui, H., Masaki, Y., Hatta, N., Doronbekov, T. K., Honda, M., Oku, N., Hatazawa, J., Nishikawa, T., & Takeda, M. (2006). Neural correlates of symptom improvement in posttraumatic stress disorder: Positron emission tomography study. In N. Kato; M. Kawata, & R. K. Pitman, (Eds.), PTSD: Brain mechanisms and clinical implications (pp. 247-254). Tokyo: Springer-Verlag.

Language: English

Format: Book Section

Abstract:
We studied the neural basis of reexperiencing in patients with PTSD using positron emission tomography (PET) and investigated the change in the neural activities from before to after improvement of PTSD symptoms. As a therapy for PTSD, we used the eye movement desensitization and reprocessing (EMDR) procedure. Although the mechanism by which EMDR acts is unclear, its efficacy for PTSD is comparable to cognitive behavioral therapy. [Text pp. 247-248][Pilots]

Keywords: Adults Arousal Brain Imaging Crime Neurophysiology Japanese Survivors Posttraumatic Stress Disorder PTSD Reexperiencing

Accuracy Verified: Yes

58. Bossini, L., Fagiolini, A., & Castrogiovanni, P. (2007, November). Neuroanatomical changes after eye movement desensitization and reprocessing (EMDR) treatment in posttraumatic stress disorder. Journal of Neuropsychiatry and Clinical Neuroscience, 19(4), 475-476.

Language: English

Format: Journal

Abstract:
Several authors have found smaller hippocampal volumes in patients with PTSD and some have suggested that psychotropic drugs may promote hippocampus neurogenesis and reverse the decrease in hippocampus volume.1 However, the only study that has investigated the effects of psychotherapy on hippocampus volume failed to show a volumetric increase after effective psychotherapy. The authors evaluated the hippocampus volumetric changes after successful EMDR treatment of a 27-year-old man with a chronic PTSD related to the suicide of his mother. After 8 weeks of EMDR treatment the patient had an increase in both left and right hippocampus volumes.[Adapted from Text] [Pilots]

Keywords: Adults Brain Imaging Brain Volume Brain Size Case Report Clinical Case Study Death of Parent Death by Suicide Effectiveness Evaluation Hippocamal Volume Hippocampus Letter Males Neuroanatomy Posttraumatic Stress Disorder Psychotherapy PTSD Survivors Treatment Treatment Effectiveness Treatment Outcome/Clinical Trial

Accuracy Verified: Yes

59. Pagani, M. (2010, Novembre). Neurobiologia e nuovi concetti fisiopatologici dell’EMDR [Neurobiology and new concepts pathophysiological EMDR]. Presentazione al "Convegno La psicotraumatologia Oncologica, Roma, Italia.

Language: Italian

Format: Conference

Abstract:
La sindrome da stress post-traumatico (PTSD) causa nel cervello cambiamenti sia anatomici sia funzionali in specifiche aree cerebrali associate alla risposta emotiva al trauma ed alla relativa insorgenza dei sintomi. Studi di immagini funzionali (tomografia ad emissione di fotone singolo, SPECT, e a emissione di positroni, PET) e strutturali (risonanza magnetica, RM) hanno evidenziato significative variazioni neuropatologiche in pazienti con PTSD durante la rivisitazione del trauma. L’impiego di queste tecniche ha consentito di fare luce sui correlati neurali della psicoterapia, rivelando i suoi effetti neurobiologici sulle funzioni cerebrali. Nell’ambito dei diversi approcci psicoterapeutici, l’EMDR (Desensibilizzazione e rielaborazione attraverso i movimenti oculari) è emerso come promettente risorsa per il trattamento del trauma e di altri disturbi d’ansia, sebbene ancora non sia stata completamente chiarita la sua modalità di azione sui circuiti neurali. Tuttavia solo un numero esiguo di studi ha indagato il substrato neurobiologico di questa psicoterapia. Verranno discussi studi che il nostro gruppo ha recentemente pubblicato su riviste internazionali e che hanno dimostrato con la SPECT come l’EMDR normalizzi il flusso ematico cerebrale nelle aree limbiche implicate nel PTSD (1) e con la RM come nei pazienti che non rispondono a terapia molte di queste aree presentino una diminuzione rilevante della densità della sostanza grigia (2). Verranno inoltre presentati i risultati preliminari del primo studio che monitora completamente con EEG una seduta EMDR e dimostra le attivazioni che i cicli di desensibilizzazione per se provocano a livello corticale e subcorticale sia durante la prima seduta che durante l’ultima quando il soggetto ha elaborato il trauma. 1. Nardo D et al. J Psychiat Res 2010; 44:477-485 2. Pagani M et al. Nucl Med Commun 2007; 28: 757-765

The syndrome of post-traumatic stress disorder (PTSD) causes changes in the brain is anatomical and functional in specific brain areas associated with emotional response to trauma and the related onset of symptoms. Studies of the functional (single photon emission computed tomography, SPECT, and emission tomography, PET) and structural (magnetic resonance imaging, MRI) have shown significant neuropathological changes in patients with PTSD during revisiting the trauma. The use of these techniques has allowed to shed light on the neural correlates of psychotherapy, revealing the neurobiological effects on brain function. Under the different psychotherapeutic approaches, EMDR (Desensitization and reprocessing through eye movements) has emerged as a promising resource for the treatment of trauma and other anxiety disorders, although still not been fully elucidated its mode of action neural circuits. However, only a small number of studies have investigated the neurobiological substrate of this psychotherapy. They will discuss studies that our group has recently published in international journals and who have demonstrated with SPECT as EMDR normalize cerebral blood flow in the limbic areas implicated in PTSD (1) and with MRI as in patients who do not respond to therapy many of these areas present a significant decrease in the density of gray matter (2). We will also present the preliminary results of the first study that monitors completely with EEG and demonstrates an EMDR session activations and cycles of desensitization if they cause in the cortex and subcortical both during the first session that during the last when the subject has developed the trauma. 1. D Nardo et al. J Psychiat Res 2010; 44:477-485 2. Pagani M et al. Nucl Med Commun 2007; 28: 757-765

Keywords: Neurobiology

Accuracy Verified: Yes

60. Pagani, M., Flumeri, F., Salmaso, D., Nardo, D., Sanchez-Crespo, A., Danielsson, A. M., Brolin, F., Jacobsson, H., Larsson, S. A., & Hogberg, G. (2008, October). Neurobiological changes in post traumatic stress disorder following treatment with eye movement desensitisation reprocessing. Presentation at the European Association of Nuclear Medicine Congress, Munich, Germany, European Journal of Nuclear Medical and Molecular Imaging, 35(Supp 2).

Language: English

Format: Conference

Abstract:
Background: Only few studies have reported functional or structural modifications in Post Traumatic Stress Disorder (PTSD) patients following pharmacological treatment or psychotherapy. Eye movement desensitization and reprocessing (EMDR) is a novel eclectic psychotherapy utilising, among other techniques, relaxation and safe place exercises, cognitive restructuring, future projections, and imaginal exposure of the trauma combined with sensory stimulation. The aim of the study was to analyse the differences in regional cerebral blood flow (rCBF) distribution and in brain volumetry before and after EMDR therapy. Subjects and Methods: Fifteen subjects with chronic PTSD following occupational health hazards were treated with five sessions of EMDR. They were assessed with psychometric scales and diagnostic interviews before and directly after treatment. SPECT, during administration of an individualised trauma script, was performed using 99mTc-HMPAO. After EMDR, the subjects were subdivided into responders (R, n=10) and non-responders (NS, n=5), based on the absence or presence, respectively, of full PTSD diagnosis. SPECT and volumetric data (MRI) analyses were carried out by Statistical Parametric Mapping (SPM2). SPECT and MRI data were covaried by age and by time elapsed from trauma to SPECT. SPECT data were further covaried by the amount of grey matter normalised by the total intracranial volume. Results: Immediate significant post-treatment changes towards normality in all scales measuring psychological status were found in responders. As compared to NR, R showed a significantly decreased tracer uptake in parieto-occipital (Brodmann Area, BA, 37, fusiform gyrus) and in primary visual cortex (BA17) and in the hippocampus (p<0.001). The opposite comparison highlighted an increased tracer uptake in left frontal cortex (BA 44; p<0.05). Structural grey matter modifications were found in visual, posterior cingulate and parieto-temporal cortex, paralleling the functional changes. Conclusion: The positive EMDR outcome corresponded to increased 99mTc-HMPAO uptake in the left dorsolateral frontal cortex, processing attention and self confidence and exerting an inhibitory effect on the amygdala whose firing is supposed to be responsible for PTSD. After successful treatment significant decreases were found in primary visual cortex, processing images of traumatic memories and flashbacks; in fusiform gyrus, processing the memories of faces, bodies and words and in the hippocampi, involved in episodic and autobiographical memories. Volumetric changes paralleled the ones in tracer uptake in all regions Taken as a whole these findings suggest that the positive clinical outcome following EMDR therapy causes functional and structural neurobiological changes towards normality.

Keywords: Brain Volumetry Neurobiological Changes Posttraumtic Stress Disorder PTSD rCBF Regional Cerebral Blood Flow

Accuracy Verified: Yes

61. Pagani, M., Salmaso, D., Flumeri, F., & Hogberg, G. (2008, June). The neurobiological substrates of PTSD and EMDR therapy. Presentation at the annual meeting of the EMDR Europe Association, London, England UK.

Language: English

Format: Conference

Abstract:
In the recent years, the number of studies using neuro-imaging to evaluate neural correlates of psychotherapy has steadily increased revealing its clear neurobiological effects on brain function across a wide range of psychiatric disorders. Functional studies by single photon emission computed tomography (SPECT) and positron emission tomography (PET) can now reliably detect changes in cerebral blood flow (CBF) and metabolism patterns, suggesting a specific role for each of the brain areas in various components of emotional processing. Investigations by magnetic resonance imaging (MRI) have also revealed psychiatry disease-related structural changes. Some regions have been reported to be associated with emotional response to trauma, and with symptom formation in posttraumatic stress disorder (PTSD). Several studies have provided evidence for the efficacy of Eye Movement Desensitization and Reprocessing therapy (EMDR) in the treatment of PTSD. However a very limited number of studies have investigated the neurobiological substrate of such therapy in clinical practice. SPECT and MRI studies, performed to examine the effects of EMDR on brain patho-physiology have provided some preliminary evidence that changes in brain CBF and structure patterns may follow effective treatment. In general in PTSD and in anxiety disorders functional deactivations parallel symptoms relief and decreased hyperreactivity to emotional and memory disturbances. Functional neuro-imaging is a promising tool for the investigation of the physiological impact of psychotherapy in anxiety related disorders and may thus pave the road for a better detection of its effects in psychiatric treatment. The scientific literature reporting PTSD/EMRD related neuro-imaging studies will be extensively reviewed.

Keywords: Neurobiology Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

62. Pagani, M. (2011, June). Neuroimaging and novel neurobiological findings in EMDR research [Neuroimaging und neuartige neurobiologische erkenntnisse in der EMDR forschung]. Presentation at the annual meeting of the EMDR Europe Association, Vienna, Austria.

Language: English

Format: Conference

Abstract:
In the recent years the number of neuroimaging studies evaluating neural correlates of psychotherapy has steadily increased revealing its clear neurobiological effects on brain function across a wide range of psychiatric disorders. Functional studies by single photon emission computed tomography (SPECT) and positron emission tomography (PET) detect changes in cerebral blood flow and metabolism patterns, identifying the brain areas processing the various components of emotional processing and/or affected by the disorders. Investigations by magnetic resonance imaging (MRI) have also revealed psychiatry disease-related structural changes. The first part of the workshop (20 minutes) will describe the neuroimaging methodologies and findings in PTSD/EMDR research with and extensive review of previous literature on the neurobiological effects of EMDR. The second part of the workshop (20 minutes) will deal with the description and implementation in research and clinic of neuropsychological testing with brief comments and discussion about their use in the recent experiments performed by our group. In the third part the EEG monitoring of a complete set of EMDR therapies in 10 patients suffering of major trauma will be presented. The relative results are the first report ever on the neurobiological changes occurring before, during and after EMDR therapy sheding light on the neuronal processes underlying its clinical efficacy. Learning objectives: The description and the discussion about the contents of the workshop will provide the audience (1) the necessary information to understand the methodological principles behind the neuroimaging techniques (PET, SPECT and MRI) and their possible applications in research and clinic; (2) the critical knowledge of the limited number of published papers in the field of EMDR-related functional and anatomical studies; (3) the basic research principles and examples to be motivated to begin, take part and/or collaborate to EMDR research in order to better understand the neural basis of this fascinating psychotherapeutic technique.

Keywords: Neurobiology Neuroimaging

Accuracy Verified: Yes

63. Pagani, M., Di Lorenzo, G., Verardo, A. R., Nicolais, G., Lauretti, G., Russo, R., Cogolo, P., Niolu, C., Ammaniti, M., Siracusano, A., & Fernandez, I. (2012, January). P-1162 Pre- intra- and post-treatment EEG imaging of EMDR - neurobiological bases of treatment efficacy. European Psychiatry, 27(Supplement 1), 1-1. doi:10.1016/S0924-9338(12)75329-4.

Language: English

Format: Journal

Abstract:
Aim: Eye Movement Desensitization and Reprocessing (EMDR) is a recognized first-line treatment for psychological trauma. However its neurobiological bases have not been disclosed yet. Methods: Electroencephalography was used for the first time to fully monitor neuronal activation during whole EMDR sessions including the autobiographical script. Nine clients with major psychological trauma were investigated during the first EMDR session and during the last one performed after processing the index trauma. Comparisons between the EEG of the first and last EMDR session and between the EEG of the clients at the first session and those of 9 controls undergoing the same EMDR procedure were performed. Results: During both script listening and bilateral stimulation EEG showed significantly higher activity in the prefrontal limbic cortex (Brodmann Areas, BA 9–10) at the first as compared to the last EMDR session. The opposite comparison showed a shift of the prevalent activity towards temporal, parietal and occipital cortical regions (BAs 20, 21, 22, 37, 17, 18, 19) with leftward lateralisation. The comparison between the 9 clients and the 9 controls confirmed the maximal activation in the limbic cortex in the clients before processing the trauma. Conclusions: The implemented methodology made possible to image for the first time the specific activations associated with the therapeutic actions contemplated by EMDR. The findings suggest cognitive processing of traumatic events following successful EMDR therapy supporting the evidence of distinct neurobiological patterns of brain activations during bilateral ocular stimulation associated with a significant relieve from negative emotional experiences.

Keywords: EEG Imaging Neurobiology

Accuracy Verified: Yes

64. Baiano, M., Bellani, M., Rambardelli, G., Perlini, C., Umit, T., Cerini, R., Balestrieri, M., Tansella, M., & Brambilla, P. (2007, October). P.1.e.007 Decreased cerebellar blood volume in schizophrenia: A perfusion weighted imaging study. European Neuropsychopharmacology, 17(Supplement 4), S284-S285.

Language: English

Format: Journal

Abstract:
No abstract available.

Keywords: Cerebellar Blood Volume Schizophrenia

Accuracy Verified: Yes

65. Staff. (2000). Phobia: When an irrational fear takes control. Films for the Humanities & Sciences, Princeton, NJ.

Language: English

Format: Video

Abstract:
For a person with a phobia, overcoming the fear--or at least learning how to resist its debilitating effects--can open the door to a fuller, freer life. This riveting two-part series uses MRI scans, body imaging, EEG tracing, and thermal photography to take an unflinching look at the biological and psychological mechanics of terror, as courageous patients seek to master their fears through medication, behavioral therapy, hypnotherapy, desensitization, virtual reality exposure therapy, the controversial technique of flooding, and a new treatment called EMDR.

Keywords: Fear Phobias Psychosocial Factors Treatment

Accuracy Verified: No

66. Lansing, K. (2003, May). Portraits in healing: A clinical study on outcomes of EMDR in the treatment for PTSD. In Advances in EMDR research. Symposium conducted at the annual meeting of the EMDR Europe Association, Rome, Italy.

Language: English

Format: Conference

Abstract:
The purpose of this study was to observe the changes that occurred with five clients diagnosed with Posttraumatic Stress Disorder through an entire course of treatment that included the use of EMDR. Special interest was given to two points of reference (1) measurements of neurological changes (observed before, during and after EMDR through brain imaging) and, (2) the clients own self report of their symptomology before the utilization of EMDR and then at the end of the segment of their treatment which incorporated EMDR.

Keywords: Police Officers Posttraumatic Stress Disorder PTSD Symposium

Accuracy Verified: Yes

67. Pagani, M. (2012, March). Pre-, intra-, and post-treatment EEG imaging of EMDR – Neurobiological bases of treatment efficacy. Poster presentation at the Scientific Programme of the 20th European Congress of Psychiatry, Prague, Czech Republic.

Language: English

Format: Conference

Abstract:
Conclusions: The implemented methodology made possible for the first time to image and represent on the cortical surface the specific brain activations associated with the therapeutic actions contemplated by EMDR protocol. These findings suggest the cognitivization of traumatic events following successful EMDR therapy with the maximal neuronal firing shifting from prefrontal-limbic to parieto-occipital associative cortex. Our results also support the evidence of distinct neurobiological patterns of brain activations during bilateral ocular stimulation.

Keywords: EEG Imaging Efficacy Neurobiology Poster

Accuracy Verified: Yes

68. Pagani, M., Di Lorenzo, G., Monaco, L., Niolu, C., Siracusano, A., Verardo, A. R., Lauretti, G., Fernandez, I., Nicolais, G., Cogolo, P., & Ammaniti, M. (2011). Pretreatment, intratreatment, and posttreatment EEG imaging of EMDR: Methodology and preliminary results from a single case. Journal of EMDR Practice and Research, 5(2), 42-56. doi:10.1891/1933-3196.5.2.42.

Language: English

Format: Journal

Abstract:
Electroencephalography (EEG), due to its peculiar time and spatial resolution, was used for the first time to fully monitor neuronal activation during the whole eye movement desensitization and reprocessing (EMDR) session, including the autobiographical script. The present case report describes the dominant cortical activations (Z-score >1.5) during the first EMDR session and in the last session after the client processed the index trauma. During the first EMDR session, prefrontal limbic cortex was essentially activated during script listening and during lateral eye movements in the desensitization phase of EMDR. In the last EMDR session, the prevalent electrical activity was recorded in temporal, parietal, and occipital cortical regions, with a clear leftward lateralization. These findings suggest a cognitive processing of the traumatic event following successful EMDR therapy and support evidence of distinct neurobiological patterns of brain activations during lateral eye movements in the desensitization phase of EMDR.

Keywords: Bilateral Ocular Stimulation Cortical Activation EEG

Accuracy Verified: Yes

69. van der Kolk, B. A., Burbridge, J. A., & Suzuki, J. (1997, June). The psychobiology of traumatic memory: Clinical implications of neuro imaging studies. Annals of the New York Academy of Sciences, 821, 99-113. doi:10.1111/j.1749-6632.1997.tb48272.x .

Language: English

Format: Journal

Abstract:
Whereas most patients with PTSD construct a narrative of their trauma over time, it is a characteristic of PTSD that sensory elements of the trauma itself continue to intrude as flashbacks and nightmares, altered states of consciousness in which the trauma is relived, unintegrated with an overall sense of self. Because traumatic memories are so fragmented, it seems reasonable to postulate that extreme emotional arousal leads to failure of the central nervous system (CNS) to synthesize the sensations related to the trauma into an integrated whole. Earlier models for a biological substrate of these phenomena have become rapidly outdated with the availability of new information derived from neuroimaging studies of patients with PTSD. The emerging body of knowledge from these studies has stimulated a gradual shift in emphasis away from the neurochemicals involved in the organisms' response to overwhelming threat to a focus on the neuronal filters concerned in the interpretation of sensory information: the interactions between the various parts of the CNS that process and interpret the meaning of incoming information, such as the amygdala, hippocampus, corpus callosum, anterior cingulte, and prefrontal cortex. [Text, p. 99]
Review Article: 58 references. This volume of the Annals was published as "Psychobiology of posttraumatic stress disorder," edited by Rachel Yehuda and Alexander C. McFarlane (New York: New York Academy of Sciences, 1997; ISBN 1-57331-078-6). These papers are the result of a conference entitled "Psychobiology of Posttraumatic Stress Disorder" sponsored by the New York Academy of Sciences, New York, 1996 September 7-10.

Keywords: Brain Imaging Dissociative Amnesia Etiology Literature Review Neuroanatomy Neuroendocrinology Psychobiology PTSD Stressors Survivors Treatment Effectiveness

Accuracy Verified: Yes

70. Corrigan, F. M. (2004). Psychotherapy as assisted homeostasis: Activation of emotional processing mediated by the anterior cingulate cortex. Medical Hypotheses, 63(6), 968-973.

Language: English

Format: Journal

Abstract:
Although psychotherapy is successful in altering emotional distress, the biological mechanism by which it achieves this has not been the subject of intensive neurobiological investigation. Mindful processing of emotion has been proposed to be a key factor in prevention of relapse in depressive illness and here that hypothesis is developed and extended to include other conditions in which emotion processing may be obstructed or dysregulated. Cognitive therapy, interpersonal psychotherapy, psycho-dynamic psychotherapy, and dialectical behaviour therapy, each in a different way and with a distinct emphasis, encourage awareness of emotions and their associated cognitions and biographies, and their varying success may depend on the degree to which they achieve activation of internal healing processes. In eye movement desensitisation and reprocessing (EMDR), the selected target is formatted for endogenous processing which is facilitated and accelerated by eye movements or alternating bilateral auditory or tactile stimulation. The ability to sustain focussed attention on the affect and its visceral, cognitive, and biographical components is postulated to activate a homeostatic process of distress resolution, seen most clearly in treatment of PTSD with EMDR, in which resolution of distress can be intense and rapid while therapist input is non-directive, although supportive, empathic, and non-judgemental. Once the therapist has helped to frame the questions, the patient's brain will find the answers needed for the resolution of the distress and all the components of the traumatic event, whether visceral, cognitive, affective, or interpersonal. The anterior cingulate cortex, especially the dorsal and rostral components, is suggested to be the key neurobiological substrate for the efficacious psychotherapeutic relief of distress, and relevant functional neuroimaging studies are summarised. One limitation of some previous imaging studies of emotion is that they have tended to use mild stimuli to discrete emotions. An alternative approach would be to image the brain during reprocessing of an unpleasant event which has profoundly affected the person so that the associated intense emotions could be clearly labelled and correlated with changes in regional brain functioning. [Author Summary]

Keywords: Cognitive Processes Cognitive Therapy Neurobiology

Accuracy Verified: Yes

71. Hopper, J. W., & van der Kolk, B. A. (2001). Retrieving, assessing, and classifying traumatic memories: A preliminary report on three case studies of a new standardized method. Journal of Aggression, Maltreatment and Trauma, 4(2), 33-71. doi:10.1300/J146v04n02_03.

Language: English

Format: Journal

Abstract:
The study of traumatic memories is still an emerging field, both methodologically and theoretically. Previous questionnaire and interview methods for studying traumatic memories have been limited in their ability to evoke and assess remembrances with the characteristics long observed by clinicians. In this article, we introduce a new standardized method that incorporates a laboratory procedure for retrieving memories of traumatic events and a clinically informed measure for assessing these memories' characteristics. We present three case studies to demonstrate the data yielded by script-driven remembering and the Traumatic Memory Inventory - Post-Script Version (TMI-PS). We then discuss subjects' script-driven remembrances in terms of methodology, theoretical classification of traumatic memories, and the interplay between the two. Finally, we critique our method in detail and offer suggestions for future research. If validated as a method for evoking and assessing traumatic memories, and shown to yield reliable data, this integrative method shows great promise for advancing both clinical and cognitive research on traumatic memories. [Author Summary]

Keywords: Adults Brain Imaging Interview Schedules Memory Impairment Memory Retrieval Techniques PTSD Assessment Instruments Stressors Survivors

Accuracy Verified: Yes

72. Lansing, K. (2013, September). The rite of return: Coming back from duty-induced PTSD. High Ground Press.

Language: English

Format: Book

Abstract:
The Rite of Return: Coming Back from Duty-Induced PTSD is written for men and women in law enforcement, first response, and the military who are struggling with duty-induced PTSD. In a field-guide format, it presents an overview of a proven treatment approach adapted specifically for this population. The book offers clear teaching on PTSD and its effects on the brain. It also provides practical training in containment techniques for increased control of symptoms and motivation for battling the tendency to isolate. The successful case outcomes described throughout the book give substantive hope for recovery from PTSD. The message throughout is that duty-induced PTSD cannot be resolved in isolation or by reading self-help books. The author’s depth of knowledge and scope of experience evident in every chapter draws the reader confidently into places where the clinical generalist cannot tread. Karen Lansing’s understanding of duty-induced PTSD goes beyond a simply clinical perspective. She has been trained in public order, ridden extensively on patrol, done 48-hour tours of duty with firefighters, and has resided and trained alongside special weapons teams on military bases. She has “kitted up” and been stuck into flashpoint sectors in “exotic places” with tactical advisors in troubled regions. The benefits emerging from that cross-pollination of disciplines are apparent in the author’s respect and understanding of the specific clinical needs of Warriors and Rescuers. It's seen in her identification of and clinical protocol for the treatment of a rare but deadly post-shooting symptom that she refers to as transitory shooter's apraxia. The benefits are also clearly seen in the clinical outcomes of those featured in this book. The Rite of Return presents a powerful argument that PTSD need not lead to an end of mission or tour of duty, or to a lifelong injury. Instead, case account after case account indicates that Lansing's treatment approach leads to quite the opposite: officers consistently emerging stronger. These outcomes are confirmed throughout the book by the testimony of SPECT brain images before and after treatment. Accompanying them are accounts of subjects after treatment responding successfully to incidents very similar to those that had culminated in their PTSD. These unsung heroes recovered, becoming more competent, more tactically skilled and more mentally resilient than they had been prior to its time-limited, but significant, intrusion into their lives. Reading between the lines of this book, it's apparent that careers and lives have been saved because of the author’s innovative approach. Her only regret is that so many have been lost to the devastation of untreated or ill-treated, duty-induced PTSD. The publication of The Rite of Return couldn’t be better timed.

Keywords: Containment Techniques Duty-Induced PTSD Military Posttraumatic Stress Disorder PTSD Transitory Shooter's Apraxia

Accuracy Verified: Yes

73. Tavanti, M., Bossini, L., Calossi, S., Lombardelli, A., Polizzotto, N., Vatti, G., Galli, R., Pieraccini F., & Castrogiovanni, P. (2008, Febbraio). Sertralina vs EMDR: Effetti sul volume ippocampale [Sertraline vs. EMDR: Effects on hippocampal volume]. Poster presentato al XII Congresso SOPSI (Società Italiana di Psicopatologia), Roma, Italia.

Language: Italian

Format: Conference

Abstract:
Molti dati sperimentali hanno mostrato che la terapia farmacologica con SSRI può incrementare il volume dell’ippocampo, invece il solo studio che ha investigato gli effetti di un tipo di psicoterapia (TEB, Terapia Eclettica Breve) non ha evidenziato alcuna efficacia sul volume ippocampale 1. Scopo del nostro studio è valutare gli effetti del trattamento con EMDR (Eye Movement Desensitization and Reprocessing) sul volume ippocampale, sui sintomi e sulle performances mnesiche di pazienti con Disturbo Post-Traumatico da Stress (DPTS). La EMDR è una terapia la cui efficacia nel DPTS è stata dimostrata in numerosi studi sperimentali. Sono stati selezionati 12 soggetti drug-free con diagnosi di DPTS alla SCID-P, senza comorbidità psichiatrica. Ogni soggetto reclutato è stato sottoposto alla prima visita (Tempo 0, Drug-Free) ad una indagine psicometrica (tramite DTS), ad una indagine neuropsicologica (tramite una batteria di test) e alla misurazione dei volumi cerebrali tramite Risonanza Magnetica. Successivamente, i 12 soggetti sono stati attribuiti in maniera random a due diversi protocolli terapeutici. Sei soggetti hanno effettuato 12 sedute di EMDR della durata di 1,5 ore, mentre sei soggetti sono stati trattati con 100 mg di sertralina. Dopo il trattamento (Tempo 1, Post-Terapia) i soggetti sono stati nuovamente sottoposti alle indagini effettuate al Tempo 0. La seconda valutazione al Tempo 1 è stata effettuata dopo tre mesi nei soggetti trattati con EMDR e dopo 6 mesi nei soggetti trattati con la sertralina, in base ai tempi medi necessari per la remissione cilinica del DPTS riportati in letteratura per i due presidi terapeutici. In questo studio verranno presentati i dati relativi alle differenze volumetriche, ai miglioramenti clinici e alla performance mnesica nei due gruppi di soggetti (soggetti sottoposti ad EMDR e soggetti trattati con sertralina) e un dettagliato confronto dei risultati ottenuti.

Many experimental data have shown that drug therapy with SSRIs may increase the volume of the hippocampus, Instead the only study that has investigated the effects of a type psychotherapy (TEB, Brief Therapy Eclectic) showed no no effect on hippocampal volume 1. Purpose of our study was to evaluate the effects of treatment with EMDR (Eye movement desensitization and reprocessing) on hippocampal volume, symptoms and performance mnesic of patients with Post-Traumatic Stress Disorder (PTSD). The EMDR is a therapy whose efficacy in PTSD is been demonstrated in numerous experimental studies. Were selected 12 subjects with a diagnosis of drug-free PTSD in the SCID-P, without psychiatric comorbidity. Each recruited subject was submitted to the first visit (Time 0, Drug-Free) at a psychometric investigation (by DTS), a neuropsychological investigation (using a battery test) and measurement of brain volume through Magnetic Resonance Imaging. Subsequently, 12 subjects have been allocated random to two different treatment protocols. Six subjects have carried out 12 sessions of EMDR duration of 1.5 hours, while six patients were treated with 100 mg of sertraline. After treatment (Time 1, Post-Therapy) subjects are were again subjected to the investigations made at the time 0. The second evaluation at Time 1 was made after three months in subjects treated with EMDR and after 6 months in subjects treated with sertraline, based on the average time needed cylinder for the remission of PTSD reported in the literature for the two therapeutic aids. In this study will be presented data on differences displacement, the clinical improvements and performance mnesic in the two groups of subjects (subjects EMDR for patients treated with sertraline) and a detailed comparison of results. Listen Read phonetically Dictionary - View detailed dictionaryGoogle Translate for my:SearchesVideosEmailPhoneChatBusinessAbout Google TranslateTurn off instant translationPrivacyHelp ©2010Business ToolsTranslator ToolkitAbout Google TranslateBlogPrivacyHelp►

Keywords: Hippocampal Volume Poster Sertraline

Accuracy Verified: Yes

74. Richardson, P., Williams, S. R., Hepenstall, S., Gregory, L., McKie, S., & Corrigan, F. (2009). A single-case fMRI study: EMDR treatment of a patient with posttraumatic stress disorder. Journal of EMDR Practice and Research, 3(1), 10-23. doi:10.1891/1933-3196.3.1.10.

Language: English

Format: Journal

Abstract:
This study assessed the effects of a session of eye movement desensitization and reprocessing (EMDR) with auditory alternating bilateral stimulation (ABS) using functional magnetic resonance imaging (fMRI) of brain activations. A case study was conducted with a female participant who was suffering from posttraumatic stress disorder following a severe assault. The fMRI scan began with safe-place imagery, for purposes of comparison, and then attention to the trauma memory without ABS. After this, ABS was provided as she began using EMDR procedures to process the traumatic memory. At postsession, the traumatic memory showed robust and significant changes on self-report measures. The initiation of the EMDR protocol with provision of ABS was associated with a marked change in brain activation within the prefrontal cortex demonstrating a ventromedial shift. The authors argue that the structure of the EMDR protocol encourages such a ventromedial activation, which is then intensified by ABS to overcome the block to information processing that has been preventing natural healing from occurring spontaneously.

Keywords: fMRI Functional Magnetic Resonance Imaging Posttraumatic Stress Disorder PTSD Single Case

Accuracy Verified: Yes

75. Pagani, M. (2008, Novembre). Sub-strato neurobiologico della sindrome da stress post-traumatico e relativo impatto funzionale e strutturale della terapia con EMDR [Neurobiological substrate of post-traumatic stress syndrome and impact on functional and structural therapy with EMDR]. Presentazione le Applicazioni Cliniche del EMDR Congresso Nazionale, Milano, Italia.

Language: Italian

Format: Conference

Abstract:
Recenti studi hanno dimostrato come la sindrome da stress post-traumatico (PTSD) possa causare nel cervello cambiamenti sia strutturali che funzionali. Studi di imaging funzionale tramite tomografia ad emissione di fotone singolo (SPECT) e ad emissione di positrone (PET) hanno evidenziato significative variazioni del flusso cerebrale in pazienti con PTSD durante la rivisitazione del trauma. A questo proposito sono stati riportati aumenti e diminuzioni di flusso nell’ippocampo, nell’amigdala, nella corteccia prefrontale mediale, nel cingolo anteriore e posteriore e nella corteccia temporale. Il modello prevalente collega i sintomi del PTSD ad una mancata inibizione dell’ amigdala, iperattivata dalla sensazione di incombente minaccia, da parte della corteccia prefrontale. E’ stato anche proposto che i cambiamenti strutturali dell’ippocampo e del cingolo anteriore rivelati dalla risonanza magnetica strutturale (RM) siano causati dalla risposta neuronale allo stress. L’obiettivo delle nostre ricerche e’ stato quello di analizzare la risposta funzionale e le variazioni strutturali in due gruppi di soggetti esposti a trauma occupazionale che hanno sviluppato (S=sintomatici, n=20) o no (NS=non sintomatici, n=27) il PTSD. Una parte dei S (n=16) è stata trattata con EMDR. La diagnosi di PTSD prima e dopo la terapia è stata basata sia sui criteri del DSM-IV sia su vari test neuropsicologici mirati. La SPECT (n=47) e la RM (n=33) sono state eseguite da 3 mesi a sei anni dal trauma e la prima è stata ripetuta dopo EMDR. I sintomi sono stati provocati da uno script individualizzato che ha riportato alla memoria il trauma e durante il quale è stato iniettato il tracciante di flusso cerebrale. Le analisi eseguite hanno mostrato differenze significative tra S e NS nella risposta del flusso cerebrale allo script. Nei 33 soggetti in cui sono state eseguite sia la SPECT che la RM sono state trovate differenze significative sia funzionali che strutturali nella corteccia temporo-parietale sinistra e nell’ippocampo, regioni nelle quali gli score dei test neuropsicologici correlano significativamente con il flusso cerebrale. Nei soggetti con remissione sintomatologica dopo EMDR (R; n=11) sono state trovate rispetto ai soggetti che non hanno risposto alla terapia (NR; n=5) significative differenze di flusso in 4 aree corticali che processano funzioni deteriorate in corso di PTSD. Diminuzioni di flusso dopo la terapia sono state registrate nei R rispetto ai NR nell’ippocampo, nel giro fusiforme (corteccia parieto-occipitale) e nella corteccia visiva primaria. L’ippocampo è sede della memoria episodica ed autobiografica; il giro fusiforme processa il riconoscimento di volti, dei corpi e delle parole; la corteccia visiva primaria custodisce la memoria visiva degli eventi. La mancata inibizione e/o l’iperattività di queste regioni nel PTSD sono responsabili della rivisitazione patologica figurata e somatica dell’evento traumatico e della presenza di flashback ed immagini allucinatorie. Viceversa la corteccia frontale dorsolaterale ha mostrato un aumento di flusso nei R. Questa regione oltre ad essere deputata ad inibire nel sistema limbico la risposta patologica a stimoli che ricordano l’evento traumatico è essenziale per i processi di attenzione e del “senso di sé”, diminuiti in corso di PTSD e recuperati in seguito alla remissione della malattia. In questi soggetti la RM ha inoltre messo in evidenza il valore predittivo delle dimensioni dell’ippocampo rispetto all’efficacia della terapia con EMDR. I nostri risultati confermano il coinvolgimento della corteccia temporo-parieto-occipitale nel PTSD e sottolineano il valore delle neuroimmagini sia nello svelare gli effetti neurobiologici dell’EMDR che determinare il valore delle indagini strutturali nel predirne l’efficacia.

Recent studies have shown that the post-traumatic stress syndrome (PTSD) may result in both structural and functional brain changes. Imaging studies using functional Single photon emission tomography (SPECT) and positron emission tomography (PET) shown significant changes in cerebral blood flow in patients with PTSD during revisiting the trauma. In this regard have been reported increases and decreases in flow hippocampus, amygdala, medial prefrontal cortex, the anterior cingulate and posterior and temporal cortex. The dominant model linking the symptoms of PTSD to a no inhibition of 'amygdala hyperactivity disorder by the sense of impending threat by the prefrontal cortex. E 'was also proposed that the structural changes of the hippocampus and anterior cingulate revealed by structural magnetic resonance imaging (MRI) are caused by the response neuronal stress. The aim of our research and 'was to analyze the response functional and structural variations in two groups of subjects exposed to occupational trauma that have developed (S = symptomatic, n = 20) or not (NS = non-symptomatic, n = 27) PTSD. Part of S (n = 16) was treated with EMDR. The diagnosis of PTSD before and after the therapy was based on both DSM-IV has on several neuropsychological tests targeting. SPECT (n = 47) and MRI (n = 33) are were performed from 3 months to six years from the trauma and the first was repeated after EMDR. Symptoms were caused by a script individual who reported to the memory of the trauma and during which were injected with a tracer of cerebral blood flow. The analysis performed showed significant differences between S and NS in the response of flow brain to the script. In the 33 subjects in which they were performed both SPECT and MRI were found significant differences in both functional and structural temporo-parietal cortex left hippocampus, regions in which the scores of neuropsychological tests correlate significantly with the flow in the brain. In subjects with symptomatic remission after EMDR (R; n = 11) were found compared with subjects who did not respond to therapy (NR, n = 5) significant differences in flow in 4 cortical areas that process functions deteriorated in the course of PTSD. Decreases in flow after treatment were recorded in R than NR hippocampus, within fusiform (parieto-occipital cortex) and in the primary visual cortex. The hippocampus is the seat of episodic memory and autobiographical, and the processes around the fusiform recognition of faces, bodies and words, the primary visual cortex preserves the memory visual events. The non-inhibition and / or 'hyperactivity of these regions in PTSD are responsible for pathological figured revisiting the traumatic event and physical and presence of flashbacks and hallucinatory images. Contrast, the dorsolateral frontal cortex has showed an increase of flow in R. This region in addition to being deputies to inhibit the system limbic response to pathological stimuli that recall the traumatic event is essential for processes of attention and the "sense of self, decreased in the course of PTSD and recovered following remission. In these subjects, MRI has also highlighted the predictive value the size of the hippocampus compared the efficacy of EMDR therapy. Our results confirm the involvement of the temporo-parietal-occipital cortex in PTSD and emphasize the value of neuroimaging in revealing both the neurobiological effects of EMDR that determine the value of the structural surveys in predicting effectiveness.

Keywords: Neurobiology Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

76. Films for the Humanities (Firm). (2000). Treating phobias 1. Princeton, NJ: Films for the Humanities & Sciences.

Language: English

Format: Video

Abstract:
In this program, the treatment of John's claustrophobia, Judith's fear of flying, and David's fear of heights--phobias described by the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) as Situational Type and Natural Environment Type--are documented. Applications of virtual reality, by Emory University's Barbara Rothbaum, and eye movement desensitization and reprocessing, by clinical psychologist Carl Nickeson, are profiled. The research of Jeffrey Gray, of the Institute of Psychiatry (London), into blood flow in the brain during moments of stress, panic, and terror is also examined. This program is part of the series "Phobia: When an Irrational Fear Takes Control." This two-part series uses MRI scans, body imaging, EEG tracing, and thermal photography to take an unflinching look at the biological and psychological mechanics of terror, as courageous patients seek to master their fears through various forms of treatment.

Keywords: Behavior Therapy Phobias

Accuracy Verified: No

77. Institute of Medicine, Committee on Treatment of Posttraumatic Stress Disorder (2008). Treatment of posttraumatic stress disorder: An assessment of the evidence. The National Academies Press, Washington, D. C. Retrieved from http://www.nap.edu/catalog/11955.html on 1/16/2009.

Language: English

Format: Other

Abstract:
This report was commissioned by the Department of Veterans Affairs (VA) to assess the scientific evidence on treatment modalities for Posttraumatic Stress Disorder (PTSD). Reviewing the PTSD treatment literature dating back to 1980, the year the disorder was first defined by the Diagnostic and Statistical Manual of the American Psychiatric Association, proved to be a challenging task. Assessing the outcomes of treatment depends entirely upon the self-report of those affected, without “objective” measures such as laboratory tests or imaging. Treatment modalities and research methods used in their evaluation have been in continuous development. The last 30 years have also seen dramatic changes in the way scientific evidence has been assessed in general with emerging international standards for conducting systematic qualitative and quantitative reviews that are quite different from the methods used in the 1980s when research on the treatment of PTSD began.
In applying a rigorous approach to the assessment of evidence that meets today’s standards, the committee identified significant gaps in the evidence that made it impossible to reach conclusions establishing the efficacy of most treatment modalities. This result was unexpected and may surprise VA and others interested in the disorder. Important treatment decisions for most modalities will need to be made without a strong body of evidence meeting current standards (the committee summarizes clinical practice guidelines developed by others in the face of this scientific uncertainty). This overall conclusion of scientific inadequacy is not a clinical practice recommendation or guideline. It is also not a judgment on the quality of the research in this field using methods acceptable at the time. The overall conclusion also adds urgency to the committee’s recommendations for a more strategic research effort that defines the relevant populations and subpopulations; develops and tests treatment modalities alone and in combination, in individual and group formats (for psychotherapy), and of various intensities and durations; uses the latest and most rigorous methods for designing and executing study protocols; and follows all study participants through the end of treatment and for meaningful periods thereafter.
The committee was also struck by the scant evidence exploring some of the possibly unique aspects of PTSD in veterans. For the most part we cannot say whether the treatment of PTSD in veterans should be the same as in civilians, and whether important subpopulations of veterans defined by age, sex, trauma type, socioeconomic status, educational level, comorbidities, and brain injury should be treated the same or differently.
The committee could only conclude that well-designed research is needed to answer the key questions regarding the efficacy of treatment modalities in veterans. Success will depend on the collaboration of VA and other government agencies, researchers, clinicians, and patient and veterans’ groups and will further require the continued support and attention of policymakers and the public. The individuals returning from current conflicts and now re-entering civilian life with this disorder deserve no less.
Alfred O. Berg, Chair
The committee concludes that the evidence is inadequate to determine the efficacy of the following psychotherapy modalities in the treatment of PTSD: • EMDR • cognitive restructuring • coping skills training [Extracted from p. 9).

Keywords: Posttraumtic Stress Disorder PTSD

Accuracy Verified: Yes

78. Committee on Treatment of Posttraumatic Stress Disorder, Institute of Medicine (2008). Treatment of posttraumatic stress disorder: An assessment of the evidence. National Academy of Sciences, Institute of Medicine(IOM), Washington, D.C.: The National Academies Press.

Language: English

Format: Publication

Abstract:
This report was commissioned by the Department of Veterans Affairs to assess the scientific evidence on treatment modalities for Posttraumatic Stress Disorder (PTSD). Reviewing the PTSD treatment literature dating back to 1980, the year the disorder was first defined by the Diagnostic and Statistical Manual of the American Psychiatric Association, proved to be a challenging task. Assessing the outcomes of treatment depends entirely upon the self-report of those affected, without “objective” measures such as laboratory tests or imaging. Treatment modalities and research methods used in their evaluation have been in continuous development. The last 30 years have also seen dramatic changes in the way scientific evidence has been assessed in general with emerging international standards for conducting systematic qualitative and quantitative reviews that are quite different from the methods used in the 1980s when research on the treatment of PTSD began.

Keywords: Posttraumatic Stress Disorder PTSD

Accuracy Verified: Yes

79. Thompson, P. (1995, June). Using EMDR with adolescents: Life changes for adlescents - an empowerment tool. Presentation at the EMDR Network Conference, Santa Monica, CA.

Language: English

Format: Conference

Abstract:
This presentation describes an EMDR protocol for working with an adolescent in such a way as to enhance their self-empowerment capabilities. As a preliminary, a medical and developmental history of the adolescent is taken from the parents, as well as obtaining their view of present problems. Using this infomation and a subsequent history obtained from the adolescent provides the basis for what may prove to be targets later. I will talk about how, in early discussions with adolescents, when my aim is to gain rapport, I often go back over some of the information their parents provided so as to obtain the teenager's views and feelings, idenfying the highs and lows in their view of their life so far. I look for where they have felt successful and powerful, and where they have suffered trauma, loss and sadness with reference to themselves as individuals and also in their family relationships. I seek to refine targets from both parental and adolescent information. I also seek to understand what the teen would like in their life and begin to introduce the idea that they can give direction to their life. I believe it is important to provide the adolescent with new or clarified information about him or her. I use psychological tests to assist in this process. I will cover briefly ways that I use the Behavior Assessment System for Children (BASC), as well as other assessment instruments such as the Strong Interest Inventory, Rorschach and Millon Adolescent Personality Inventory (MAPI), to give both the adolescent and me important information. Because the information stems from a comparison with the general population, I can present it more objectively than if it were solely my assessment of them. The adolescent decides what fits them and what doesn't. This process allows us jointly to identify problems and to look for ways to handle them. Emphasis is always placed on the adolescent having the power - the information about themselves is power. What they choose to do with it breeds power. They are in control. This process usually leads to a further explanation of EMDR and how they might choose to work with me using EMDR. In summary, I will cover : Helping the adolescent look at choices as giving freedom Presenting EMDR as a way of having more choices; Looking at behavior problems as habits that can be changed if desired. Encouraging the use of imagination, imaging, finding a safe place and helping make changes; Taking the position of being their coach for their effort to develop the kind of life they want. Looking at what they think stands in their way and what they can do to change it. Identifying negative cognition from these blocks. Using EMDR in the context of what they want. Building Self Esteem through goal attainment-EMDR as a tool for performance. Coaching for positive change and clear thinking. Teaching self direction and organization reinforcing with EMDR. Teaching self coaching.

Keywords: Adolescents Self Coaching

Accuracy Verified: Yes

80. Kreitzberg, J. (2011). Using magneto encephalography to determine the therapeutic efficacy of EMDR in the treatment of PTSD. Symposium presented at the Annual Linfield College Science Symposium.

Language: English

Format: Conference

Abstract:
Post-traumatic stress disorder (PTSD) is a condition that can be produced by traumatic experiences. A new study has shown that a brain scan called magneto encephalography (MEG) can identify people who have PTSD with an accuracy of 95%. Sensors measure tiny magnetic fields generated by currents flowing in and around neurons. In addition they have recently stated in the Journal of Neural Engineering that they can now watch the brain as it experiences PTSD. Imaging shows that the brain becomes hyperactive in the right temporal lobe, the location responsible for memory. Besides diagnosing PTSD, the researchers also are able to judge the severity of how much patients are suffering. Eye-movement desensitization and reprocessing (EMDR) was designed in 1987 as a treatment for PTSD. EMDR is a structured eight-phase therapy that allows for adequate reprocessing of dysfunctionally stored memory. In the processing phases the client attends to the disturbing memory in brief intervals of 15-30 seconds while also experiencing bilateral stimulation (eye movements, tones or tapping). The eight phases integrate effective elements of psychodynamic, imaginal exposure, cognitive therapy, interpersonal, experiential, physiological and somatic therapies. Now that we can locate specific biomarkers for PTSD using MEG, my hypothesis is that we will find a statistically significant difference between the control group and the group that has EMDR treatment, and that EMDR will be shown to be effective in resolving PTSD as measured by pre and post therapy MEG scans. Also using the MEG, we may be able to observe those brain actions responsible for the therapeutic efficacy of EMDR and isolate which components of EMDR trigger those brain actions. The significance of finding the answer to these questions could potentially help millions of people overcome years of suffering from psychological pain due to the after effects of severe trauma and restore them to productive lives. It could establish the status of EMDR, assisting in the decision of whether it should be listed among the evidence-based, best-practice therapy modalities and covered by insurance. Also knowing the underlying pathophysiology could contribute to the evolution, revision and refinement of diagnostic constructs for PTSD.

Keywords: Efficacy Magneto Encephalography Posttraumatic Stress Disorder PTSD Treatment

Accuracy Verified: Yes

81. Levin, P., Lazrove, S., & van der Kolk, B. (1999, January-April). What psychological testing and neuroimaging tell us about the treatment of posttraumatic stress disorder by eye movement desensitization and reprocessing. Journal of Anxiety Disorders, 13(1-2), 159-172. doi:10.1016/S0887-6185(98)00045-0.

Language: English

Format: Journal

Abstract:
To better understand the pathophysiology and treatment of Posttraumatic Stress Disorder (PTSD), standard psychological testing, Rorschach Ink Blot testing, and neuroimaging using Single Photon Emission Computed Tomography (SPECT) were administered to subjects with PTSD prior to and following three sessions of Eye Movement Desensitization and Reprocessing (EMDR). Using this within-subject design, data from one of six subjects in our series is presented as a case report. Following EMDR, the subject experienced improvement in his level of distress, which correlated with decrements in PTSD and depressive symptomatology on psychological testing. Analysis of the Rorschach data corroborated these changes. Among other findings, the Hypervigilance Index went from positive to negative, indicating that the subject was spending less time scanning the environment for threats, and available ego resources also increased, as measured by the Experience Actual variable. Upon recall of the traumatic memory during SPECT scanning, two areas of the brain were hyperactive post-EMDR treatment relative to pretreatment: the anterior cingulate gyrus and the left frontal lobe. These changes were consistent with summed data from four out of six subjects in the ongoing study. An important implication of these findings is that successful treatment of PTSD does not reduce arousal at the limbic level, but instead, enhances the ability to differentiate real from imagined threat. The psychology and neurophysiology of PTSD are discussed in greater detail. (ScienceDirect)

Keywords: Adults Americans Brain Imaging Empirical Study Posttraumatic Stress Disorder PTSD Treatment Effectiveness

Accuracy Verified: Yes

82. Bisping, V. S. (2011). Wirksamkeit von eye movement desensitization and reprocessing (EMDR) bei zahnbehandlungsphobie [Efficacy of eye movement desensitization and reprocessing (EMDR) treatment for dental phobia]. Universitätsklinikum Münster, Kliniken, Psychosomatik und Psychotherapie,Forschung, Munster, Deutschland .

Language: German

Format: Dissertation/Thesis

Abstract:
In dieser Studie werden 30 Patienten mit Zahnbehandlungsphobie in einem Warte-Kontrollgruppen-Design mit Eye Movement Desensitization and Reprocessing (EMDR) behandelt. Die manualisierte Intervention umfasst drei ca. 90-minütige Sitzungen. Vor und nach der Behandlung wird die Angst vor der Zahnbehandlung mit Fragebögen und einem Verhaltenstest erfasst. Darüber hinaus werden bildgebende Untersuchungen durchgeführt (siehe folgendes Projekt).

In this study, 30 patients treated with dental anxiety in a wait-control group design with Eye Movement Desensitization and Reprocessing (EMDR). The manualized intervention includes three 90-minute sessions. Before and after the treatment, the fear of dental treatment with a behavior test questionnaires and is detected. In addition, imaging studies are performed (see next project: Erfassung neurobiologischer Korrelate der EMDR-Behandlung bei Patienten mit Zahnbehandlungsangst, by S. Doering, V. Bisping, N. Nora Liebergesell, B. Höffkes, M. Junghöfer, C. Dobel).

Keywords: Dental Phobia

Accuracy Verified: Yes