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1. Ohtani, T., & Matsuo, K. (2006). Functional abnormality of the prefrontal cortex in posttraumatic stress disorder: Psychophysiology and treatment studies assessed by near-infrared spectroscopy. In N. Kato; M. Kawata, & Pitman, R. K (Eds.), PTSD: Brain mechanisms and clinical implications (pp. 235-245). Tokyo: Springer-Verlag.

Language: English

Format: Book Section

Abstract:
A growing number of functional neuroimaging studies on PTSD have described the abnormal response of amygdala and prefrontal cortex to traumatic stimuli. Abnormal activation of some parts of the prefrontal cortex might possibly be involved in the pathophysiology of PTSD. [Adapted from Text, pp. 235-236]TOPICS TREATED: Near-infrared spectroscopy (NIRS); NIRS studies in PTSD; Neuroimaging studies of treatment in PTSD (Selective-serotonin reuptake inhibitor [SSRI] and Eye movement desensitization and reprocessing [EMDR].([Adapted from Text, pp. 235-236] [Pilots]

Keywords: Brain Imaging  Neuroanatomy  Posttraumatic Stress Disorder  PTSD  

Accuracy Verified: Yes

2. Bossini, L., Fagiolini, A., & Castrogiovanni, P. (2007, November). Neuroanatomical changes after eye movement desensitization and reprocessing (EMDR) treatment in posttraumatic stress disorder. Journal of Neuropsychiatry and Clinical Neuroscience, 19(4), 475-476.

Language: English

Format: Journal

Abstract:
Several authors have found smaller hippocampal volumes in patients with PTSD and some have suggested that psychotropic drugs may promote hippocampus neurogenesis and reverse the decrease in hippocampus volume.1 However, the only study that has investigated the effects of psychotherapy on hippocampus volume failed to show a volumetric increase after effective psychotherapy. The authors evaluated the hippocampus volumetric changes after successful EMDR treatment of a 27-year-old man with a chronic PTSD related to the suicide of his mother. After 8 weeks of EMDR treatment the patient had an increase in both left and right hippocampus volumes.[Adapted from Text] [Pilots]

Keywords: Adults  Brain Imaging  Brain Volume  Brain Size  Case Report  Clinical Case Study  Death of Parent  Death by Suicide  Effectiveness Evaluation  Hippocamal Volume  Hippocampus  Letter  Males  Neuroanatomy  Posttraumatic Stress Disorder  Psychotherapy  PTSD  Survivors  Treatment  Treatment Effectiveness  Treatment Outcome/Clinical Trial  

Accuracy Verified: Yes

3. van der Kolk, B. A., Burbridge, J. A., & Suzuki, J. (1997, June). The psychobiology of traumatic memory:  Clinical implications of neuro imaging studies. Annals of the New York Academy of Sciences, 821, 99-113. doi:10.1111/j.1749-6632.1997.tb48272.x .

Language: English

Format: Journal

Abstract:
Whereas most patients with PTSD construct a narrative of their trauma over time, it is a characteristic of PTSD that sensory elements of the trauma itself continue to intrude as flashbacks and nightmares, altered states of consciousness in which the trauma is relived, unintegrated with an overall sense of self. Because traumatic memories are so fragmented, it seems reasonable to postulate that extreme emotional arousal leads to failure of the central nervous system (CNS) to synthesize the sensations related to the trauma into an integrated whole. Earlier models for a biological substrate of these phenomena have become rapidly outdated with the availability of new information derived from neuroimaging studies of patients with PTSD. The emerging body of knowledge from these studies has stimulated a gradual shift in emphasis away from the neurochemicals involved in the organisms' response to overwhelming threat to a focus on the neuronal filters concerned in the interpretation of sensory information: the interactions between the various parts of the CNS that process and interpret the meaning of incoming information, such as the amygdala, hippocampus, corpus callosum, anterior cingulte, and prefrontal cortex. [Text, p. 99]
Review Article: 58 references. This volume of the Annals was published as "Psychobiology of posttraumatic stress disorder," edited by Rachel Yehuda and Alexander C. McFarlane (New York: New York Academy of Sciences, 1997; ISBN 1-57331-078-6). These papers are the result of a conference entitled "Psychobiology of Posttraumatic Stress Disorder" sponsored by the New York Academy of Sciences, New York, 1996 September 7-10.

Keywords: Brain Imaging  Dissociative Amnesia  Etiology  Literature Review  Neuroanatomy  Neuroendocrinology  Psychobiology  PTSD  Stressors  Survivors  Treatment Effectiveness  

Accuracy Verified: Yes